Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies

• Published in: Chemical Society reviews Vol. 41; no. 8; pp. 3264 - 3279
• Main Authors: Barry, Nicolas P. E, Sadler, Peter J
• Format: Journal Article
• Language: English
• Published: England 23.03.2012
• Subjects: Boranes - chemistry; boron; Cell Line, Tumor; Chemistry Techniques, Synthetic - methods; drugs; geometry; Humans; iridium; Iridium - chemistry; medicine; neutrons; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Organometallic Compounds - therapeutic use; osmium; Osmium - chemistry; pharmacology; proteins; rhodium; Rhodium - chemistry; ruthenium; Ruthenium - chemistry; therapeutics

This review describes how the incorporation of dicarba- closo -dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine. Such a combination not only has unexplored potential in tradit...