Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies

This review describes how the incorporation of dicarba- closo -dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine. Such a combination not only has unexplored potential in tradit...

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Published inChemical Society reviews Vol. 41; no. 8; pp. 3264 - 3279
Main Authors Barry, Nicolas P. E, Sadler, Peter J
Format Journal Article
LanguageEnglish
Published England 23.03.2012
Subjects
Boranes - chemistry
boron
Cell Line, Tumor
Chemistry Techniques, Synthetic - methods
drugs
geometry
Humans
iridium
Iridium - chemistry
medicine
neutrons
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Organometallic Compounds - therapeutic use
osmium
Osmium - chemistry
pharmacology
proteins
rhodium
Rhodium - chemistry
ruthenium
Ruthenium - chemistry
therapeutics
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Summary:This review describes how the incorporation of dicarba- closo -dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine. Such a combination not only has unexplored potential in traditional areas such as Boron Neutron Capture Therapy agents, but also as pharmacophores for the targeting of biologically important proteins and the development of targeted drugs. The synthetic pathways used for the syntheses of dicarba- closo -dodecarboranes-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium are also reviewed. Complexes with a wide variety of geometries and characteristics can be prepared. Examples of addition reactions on the metal centre, BH activation, transmetalation reactions and/or direct formation of metalmetal bonds are discussed (103 references). This review describes how the incorporation of dicarba- closo -dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine.
Bibliography:Professor Peter Sadler obtained his BA, MA and DPhil at the University of Oxford. Subsequently he was a Medical Research Council Research Fellow at the University of Cambridge and National Institute for Medical Research. From 197396 he was Lecturer, Reader and Professor at Birkbeck College, University of London, and from 19962007 Crum Brown Chair of Chemistry at the University of Edinburgh. In June 2007 he took up a Chair in Chemistry at the University of Warwick. He is a Fellow of the Royal Society of Edinburgh (FRSE) and the Royal Society of London (FRS), and a European Research Council Advanced Investigator. His research interests are centred on the chemistry of metals in medicine.
Nicolas Barry was born in Paris in 1983. In 2008, he received his Masters degree in Chemistry from the Universit de Rennes, France. From 2008 to 2011 he worked under the supervision of Prof. Sss-Fink and Dr Therrien at the Universit de Neuchtel, Switzerland, where he obtained his PhD in Organometallic Chemistry. Presently, he is a Swiss National Science Foundation postdoctoral fellow in the laboratory of Prof. Peter Sadler at the University of Warwick.
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ISSN:0306-0012
1460-4744
1460-4744
DOI:10.1039/c2cs15300a