Natural products: protective effects against ischemia-induced retinal injury

Ischemic retinal damage, a common condition associated with retinal vascular occlusion, glaucoma, diabetic retinopathy, and other eye diseases, threatens the vision of millions of people worldwide. It triggers excessive inflammation, oxidative stress, apoptosis, and vascular dysfunction, leading to...

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Published inFrontiers in pharmacology Vol. 14; p. 1149708
Main Authors He, Qianxiong, Xiao, Liuyi, Shi, Yuanjiang, Li, Wanrong, Xin, Xiaorong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.04.2023
Subjects
ischemia
natural product
neuroprotective
Pharmacology
retinal ischemia
treatment
treatment
retinal ischemia
natural product
neuroprotective
ischemia
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Summary:Ischemic retinal damage, a common condition associated with retinal vascular occlusion, glaucoma, diabetic retinopathy, and other eye diseases, threatens the vision of millions of people worldwide. It triggers excessive inflammation, oxidative stress, apoptosis, and vascular dysfunction, leading to the loss and death of retinal ganglion cells. Unfortunately, minority drugs are available for treating retinal ischemic injury diseases, and their safety are limited. Therefore, there is an urgent need to develop more effective treatments for ischemic retinal damage. Natural compounds have been reported to have antioxidant, anti-inflammatory, and antiapoptotic properties that can be used to treat ischemic retinal damage. In addition, many natural compounds have been shown to exhibit biological functions and pharmacological properties relevant to the treatment of cellular and tissue damage. This article reviews the neuroprotective mechanisms of natural compounds involve treating ischemic retinal injury. These natural compounds may serve as treatments for ischemia-induced retinal diseases.
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Edited by: Xiaming Liu, Huazhong University of Science and Technology, China
Reviewed by: Prabhat Upadhyay, Massachusetts General Hospital and Harvard Medical School, United States
Pan Long, Western Theater General Hospital, China
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2023.1149708