Magnetic iron oxide nanoparticle-loaded hydrogels for photothermal therapy of cancer cells
Non-invasive photothermal therapy (PTT) is a competitive treatment for solid tumors, while the efficacy is largely dependent on the effective retention of photothermal converters in tumor tissues. Herein, the development of iron oxide (Fe O ) nanoparticle-loaded alginate (ALG) hydrogel platform for...
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Published in | Frontiers in bioengineering and biotechnology Vol. 11; p. 1130523 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
16.03.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Non-invasive photothermal therapy (PTT) is a competitive treatment for solid tumors, while the efficacy is largely dependent on the effective retention of photothermal converters in tumor tissues.
Herein, the development of iron oxide (Fe
O
) nanoparticle-loaded alginate (ALG) hydrogel platform for PTT of colorectal cancer cells is reported. Fe
O
nanoparticles synthesized
coprecipitation method after reaction of 30 min have a small size (61.3 nm) and more suitable surface potential, and can mediate PTT under near-infrared (NIR) laser irradiation. The premix of Fe
O
nanoparticles and ALG hydrogel precursors can be gelatinized by Ca
-mediated cross-linking to form this therapeutic hydrogel platform.
The formed Fe
O
nanoparticles can be effectively taken up by CT26 cancer cells and induce the death of CT26 cells
under NIR laser irradiation because of their excellent photothermal property. In addition, Fe
O
nanoparticle-loaded ALG hydrogels show negligible cytotoxicity at the studied concentration range, but can significantly kill cancer cells after PTT effect.
This ALG-based hydrogel platform provides a valuable reference for subsequent in vivo studies and other related studies on Fe
O
nanoparticle-loaded hydrogels. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Ricardo João Borges Pinto, University of Aveiro, Portugal Reviewed by: Xiaojun Zhou, Donghua University, China Edited by: Yu Luo, Shanghai University of Engineering Sciences, China This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology |
ISSN: | 2296-4185 2296-4185 |
DOI: | 10.3389/fbioe.2023.1130523 |