Non-invasive brain stimulation for patient with autism: a systematic review and meta-analysis
To comprehensively evaluate the efficacy of non-invasive brain stimulation (NIBS) in patients with autism spectrum disorder (ASD) in randomized controlled trials (RCT), providing a reference for future research on the same topic. Five databases were searched (Pubmed, Web of Science, Medline, Embase,...
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Published in | Frontiers in psychiatry Vol. 14; p. 1147327 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
29.06.2023
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Subjects | |
Online Access | Get full text |
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Summary: | To comprehensively evaluate the efficacy of non-invasive brain stimulation (NIBS) in patients with autism spectrum disorder (ASD) in randomized controlled trials (RCT), providing a reference for future research on the same topic.
Five databases were searched (Pubmed, Web of Science, Medline, Embase, and Cochrane library) and tracked relevant references, Meta-analysis was performed using RevMan 5.3 software.
Twenty-two references (829 participants) were included. The results of the meta-analysis showed that NIBS had positive effects on repetitive and stereotypical behaviors, cognitive function, and executive function in autistic patients. Most of the included studies had a moderate to high risk of bias, Mainly because of the lack of blinding of subjects and assessors to treatment assignment, as well as the lack of continuous observation of treatment effects.
Available evidence supports an improvement in some aspects of NIBS in patients with ASD. However, due to the quality of the original studies and significant publication bias, this evidence must be treated with caution. Further large multicenter randomized double-blind controlled trials and appropriate follow-up observations are needed to further evaluate the specific efficacy of NIBS in patients with ASD. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Youlin Long, Sichuan University, China; Lisa Asta, University of Modena and Reggio Emilia, Italy; Diego Centonze, University of Rome Tor Vergata, Italy Edited by: Antonio M. Persico, University of Modena and Reggio Emilia, Italy |
ISSN: | 1664-0640 1664-0640 |
DOI: | 10.3389/fpsyt.2023.1147327 |