Basophils absence predicts poor prognosis and indicates immunosuppression of patients in intensive care units

• Published in: Scientific reports Vol. 13; no. 1; p. 18533
• Main Authors: Chen, Xiao, Zhu, Xiaofeng, Zhuo, Huichang, Lin, Jiandong, Lin, Xian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/409; 692/308/53; 692/308/575; Hospitals; Humanities and Social Sciences; Immunity; Immunosuppression; Intensive care; Intensive care units; Leukocytes (basophilic); Medical records; Mortality; multidisciplinary; Patients; Prognosis; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-45865-y

Immune cells and immunity are associated with the prognosis of patients with critical illness. Here, medical records retrospectively extracted from the Medical Information Mart for Intensive Care IV were used for screening an immune-related biomarker in intensive care units (ICU) patients and applied for validating the identified indicator in septic patients. In this work, the count of innate immune cells, basophils, harbored a superior role in predicting ICU patients’ prognosis compared with those of other blood immune cells (OR 0.013, 95% CI 0.001, 0.118, P  < 0.001). Importantly, basophils absence during ICU stay was positively correlated with the 28-day mortality of ICU patients and served as an independent predictor of ICU patients’ prognosis (OR 3.425, 95% CI 3.717–3.165, P  < 0.001). Moreover, the association between critical illness progression, poor outcome, and basophils absence was verified in septic patients. Subsequent investigations revealed the positive relationship between basophils absence and immunosuppression, and suggested the potential of basophils-mediated immunity in predicting the 28-day mortality of ICU patients. Collectively, we identify basophils absence during ICU stay as a novel and unfavorable indicator for evaluating the prognosis of ICU patients and recognizing a branch of ICU patients potentially suitable for intensified treatment and immunoenhancement therapy.