Quantitative evaluation of the spinal cord compression in patients with cervical spondylotic myelopathy using synthetic MRI

• Published in: Frontiers in physiology Vol. 14; p. 1140870
• Main Authors: Liu, Qiufeng, Shao, Haoyue, Liu, Chaoxu, Liu, Weiyin Vivian, Saeed, Azzam, Zhang, Qiya, Lu, Jun, Zhang, Guiling, Li, Li, Tang, Xiangyu, Du, Guanghui, Zhu, Wenzhen
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.04.2023
• Subjects: cervical spondylotic myelopathy; magnetic resonance image; Physiology; quantitative evaluation; spinal cord; synthetic; magnetic resonance image; synthetic; spinal cord; cervical spondylotic myelopathy; quantitative evaluation
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2023.1140870

Objectives: This work aimed to investigate the feasibility and diagnostic value of synthetic MRI, including T1, T2 and PD values in determining the severity of cervical spondylotic myelopathy (CSM). Methods: All subjects (51 CSM patients and 9 healthy controls) underwent synthetic MRI scan on a 3.0T GE MR scanner. The cervical canal stenosis degree of subjects was graded 0—III based on the method of a MRI grading system. Regions of interest (ROIs) were manually drawn at the maximal compression level (MCL) by covering the whole spinal cord to generate T1 MCL , T2 MCL , and PD MCL values in grade I-III groups. Besides, anteroposterior (AP) and transverse (Trans) diameters of the spinal cord at MCL were measured in grade II and grade III groups, and relative values were calculated as follows: rAP = AP MCL /AP normal , rTrans = Trans MCL /Trans normal . rMIN = rAP/rTrans. Results: T1 MCL value showed a decreasing trend with severity of grades (from grade 0 to grade II, p < 0.05), while it increased dramatically at grade III. T2 MCL value showed no significant difference among grade groups (from grade 0 to grade II), while it increased dramatically at grade III compared to grade II ( p < 0.05). PD MCL value showed no statistical difference among all grade groups. rMIN of grade III was significantly lower than that of grade II ( p < 0.05). T2 MCL value was negatively correlated with rMIN, whereas positively correlated with rTrans. Conclusion: Synthetic MRI can provide not only multiple contrast images but also quantitative mapping, which is showed promisingly to be a reliable and efficient method in the quantitative diagnosis of CSM.