Acute oxygen sensing by vascular smooth muscle cells

• Published in: Frontiers in physiology Vol. 14; p. 1142354
• Main Authors: Moreno-Domínguez, Alejandro, Colinas, Olaia, Smani, Tarik, Ureña, Juan, López-Barneo, José
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.03.2023
• Subjects: acute O2 sensing; hypoxic arterial vasodilation; hypoxic pulmonary vasoconstriction; ion channels; mitochondria; Physiology; vascular smooth muscle; vascular smooth muscle; hypoxic arterial vasodilation; hypoxic pulmonary vasoconstriction; acute O2 sensing; mitochondria; ion channels
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2023.1142354

An adequate supply of oxygen (O ) is essential for most life forms on earth, making the delivery of appropriate levels of O to tissues a fundamental physiological challenge. When O levels in the alveoli and/or blood are low, compensatory adaptive reflexes are produced that increase the uptake of O and its distribution to tissues within a few seconds. This paper analyzes the most important acute vasomotor responses to lack of O (hypoxia): hypoxic pulmonary vasoconstriction (HPV) and hypoxic vasodilation (HVD). HPV affects distal pulmonary (resistance) arteries, with its homeostatic role being to divert blood to well ventilated alveoli to thereby optimize the ventilation/perfusion ratio. HVD is produced in most systemic arteries, in particular in the skeletal muscle, coronary, and cerebral circulations, to increase blood supply to poorly oxygenated tissues. Although vasomotor responses to hypoxia are modulated by endothelial factors and autonomic innervation, it is well established that arterial smooth muscle cells contain an acute O sensing system capable of detecting changes in O tension and to signal membrane ion channels, which in turn regulate cytosolic Ca levels and myocyte contraction. Here, we summarize current knowledge on the nature of O sensing and signaling systems underlying acute vasomotor responses to hypoxia. We also discuss similarities and differences existing in O sensors and effectors in the various arterial territories.