Enhanced electric field sensitivity of quantum dot/rod two-photon fluorescence and its relevance for cell transmembrane voltage imaging

The optoelectronic properties of semiconductor nanoparticles make them valuable candidates for the long-term monitoring of transmembrane electric fields in excitable cells. In this work, we show that the electric field sensitivity of the fluorescence intensity of type-I and quasi-type-II quantum dot...

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Published inNanophotonics (Berlin, Germany) Vol. 10; no. 9; pp. 2407 - 2420
Main Authors Jooken, Stijn, de Coene, Yovan, Deschaume, Olivier, Zámbó, Dániel, Aubert, Tangi, Hens, Zeger, Dorfs, Dirk, Verbiest, Thierry, Clays, Koen, Callewaert, Geert, Bartic, Carmen
Format Journal Article
LanguageEnglish
Published Berlin De Gruyter 08.07.2021
Walter de Gruyter GmbH
Subjects
Chemical Sciences
electric field
Electric fields
Electric potential
Excitation
Fluorescence
Nanoparticles
Optoelectronics
Photons
quantum dot/rod
Quantum dots
Rods
semiconductor nanoparticle
Sensitivity enhancement
two-photon fluorescence
Voltage
voltage sensing
Voltage sensing
Semiconductor nanoparticles
Electric field
Quantum dot/rod
Two-photon fluorescence
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Summary:The optoelectronic properties of semiconductor nanoparticles make them valuable candidates for the long-term monitoring of transmembrane electric fields in excitable cells. In this work, we show that the electric field sensitivity of the fluorescence intensity of type-I and quasi-type-II quantum dots and quantum rods is enhanced under two-photon excitation compared to single-photon excitation. Based on the superior electric field sensitivity of the two-photon excited fluorescence, we demonstrate the ability of quantum dots and rods to track fast switching E-fields. These findings indicate the potential of semiconductor nanoparticles as cellular voltage probes in multiphoton imaging.
ISSN:2192-8606
2192-8614
2192-8614
DOI:10.1515/nanoph-2021-0077