Hyaluronate in vasculogenesis [Chicken embryos]

Limb buds of chicken embryos contain within the peripheral mesoderm an avascular zone that is rich in hyaluronic acid. Epithelial tissues that synthesize large amounts of hyaluronic acid relative to other glycosaminoglycans caused avascularity when implanted into normally vascular wing mesoderm. Epi...

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Published inScience (American Association for the Advancement of Science) Vol. 220; no. 4602; pp. 1177 - 1179
Main Authors Feinberg, Richard N., Beebe, David C.
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 10.06.1983
American Association for the Advancement of Science
Subjects
Animals
Blood vessels
Blood Vessels - embryology
Cardiovascular research
Cardiovascular system
Chick Embryo
Connective tissues
Ectoderm
Ectoderm - metabolism
Embryos
Epithelium
Epithelium - metabolism
Glycosaminoglycans
Growth
Hyaluronic Acid - physiology
Limb buds
Mesoderm
Mesoderm - metabolism
Polymers
Wings, Animal - blood supply
Wings, Animal - embryology
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Summary:Limb buds of chicken embryos contain within the peripheral mesoderm an avascular zone that is rich in hyaluronic acid. Epithelial tissues that synthesize large amounts of hyaluronic acid relative to other glycosaminoglycans caused avascularity when implanted into normally vascular wing mesoderm. Epithelia that synthesize little hyaluronic acid did not cause avascularity. Elvax implants containing hyaluronic acid caused the formation of avascular zones, whereas similar implants containing other glycosaminoglycans did not give rise to avascular zones. Hyaluronic acid may thus play a role in determining the location of blood vessels in the embryo.
Bibliography:L
L50
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.6857242