Regulating bile acids signaling for NAFLD: molecular insights and novel therapeutic interventions

Nonalcoholic fatty liver disease (NAFLD) emerges as the most predominant cause of liver disease, tightly linked to metabolic dysfunction. Bile acids (BAs), initially synthesized from cholesterol in the liver, undergo further metabolism by gut bacteria. Increasingly acknowledged as critical modulator...

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Published inFrontiers in microbiology Vol. 15; p. 1341938
Main Authors Wei, Meilin, Tu, Wei, Huang, Genhua
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 03.06.2024
Subjects
bile acids
FXR
gut liver axis
gut microbiota
Microbiology
NAFLD
TGR5
FXR
TGR5
NAFLD
gut liver axis
bile acids
gut microbiota
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Summary:Nonalcoholic fatty liver disease (NAFLD) emerges as the most predominant cause of liver disease, tightly linked to metabolic dysfunction. Bile acids (BAs), initially synthesized from cholesterol in the liver, undergo further metabolism by gut bacteria. Increasingly acknowledged as critical modulators of metabolic processes, BAs have been implicated as important signaling molecules. In this review, we will focus on the mechanism of BAs signaling involved in glucose homeostasis, lipid metabolism, energy expenditure, and immune regulation and summarize their roles in the pathogenesis of NAFLD. Furthermore, gut microbiota dysbiosis plays a key role in the development of NAFLD, and the interactions between BAs and intestinal microbiota is elucidated. In addition, we also discuss potential therapeutic strategies for NAFLD, including drugs targeting BA receptors, modulation of intestinal microbiota, and metabolic surgery.
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Kaifeng Guo, Fudan University, China
Reviewed by: Hannelouise Kissow, University of Copenhagen, Denmark
Edited by: Mauro Cataldi, University of Naples Federico II, Italy
Yiting Xu, Shanghai Jiao Tong University, China
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2024.1341938