Mitochondrial dynamics: the intersection of form and function

Mitochondria within a cell exist as a population in a dynamic -morphological continuum. The balance of mitochondrial fusion and fission dictates a spectrum of shapes from interconnected networks to fragmented individual units. This plasticity bestows the adaptive flexibility needed to adjust to chan...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 748; p. 13
Main Authors Ferree, Andrew, Shirihai, Orian
Format Journal Article
LanguageEnglish
Published United States 01.01.2012
Subjects
Animals
Humans
Intracellular Signaling Peptides and Proteins - physiology
Membrane Fusion
Mitochondria - physiology
Mitochondrial Proteins - physiology
Oncogene Proteins - physiology
Protein Deglycase DJ-1
Protein Kinases - physiology
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Summary:Mitochondria within a cell exist as a population in a dynamic -morphological continuum. The balance of mitochondrial fusion and fission dictates a spectrum of shapes from interconnected networks to fragmented individual units. This plasticity bestows the adaptive flexibility needed to adjust to changing cellular stresses and metabolic demands. The mechanisms that regulate mitochondrial dynamics, their importance in normal cell biology, and the roles they play in disease conditions are only beginning to be understood. Dysfunction of mitochondrial dynamics has been identified as a possible disease mechanism in Parkinson's disease. This chapter will introduce the budding field of mitochondrial dynamics and explore unique characteristics of affected neurons in Parkinson's disease that increase susceptibility to disruptions in mitochondrial dynamics.
ISSN:0065-2598
DOI:10.1007/978-1-4614-3573-0_2