Central Nervous System and Ocular Manifestations in Puumala Hantavirus Infection

• Published in: Viruses Vol. 13; no. 6; p. 1040
• Main Authors: Hautala, Nina, Partanen, Terhi, Kubin, Anna-Maria, Kauma, Heikki, Hautala, Timo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.05.2021; MDPI
• Subjects: Aerosols; Animals; Antibodies, Viral - blood; Arvicolinae - virology; Blood-brain barrier; Central nervous system; Central Nervous System Diseases - virology; Convulsions & seizures; Creatinine; Cytokines; Disease Reservoirs - virology; Encephalitis; Eye Diseases - virology; Fibroblasts; Hantavirus; Headaches; Hematuria; Hemorrhage; Hemorrhagic fever with renal syndrome; Hemorrhagic Fever with Renal Syndrome - complications; Humans; Infections; intraocular pressure; myopic shift; Nausea; Nervous system; Oliguria; Patients; Permeability; Pituitary gland; Population Dynamics; Proteins; Puumala virus - pathogenicity; Review; Sleep disorders; Thrombocytopenia; Vertigo; visual disorders; Vomiting; myopic shift; visual disorders; intraocular pressure; encephalitis; hantavirus; central nervous system
• ISSN: 1999-4915; 1999-4915
• DOI: 10.3390/v13061040

Puumala hantavirus (PUUV), carried and spread by the bank vole ( ), causes a mild form of hemorrhagic fever with renal syndrome (HFRS) called nephropathia epidemica (NE). Acute high fever, acute kidney injury (AKI), thrombocytopenia, and hematuria are typical features of this syndrome. In addition, headache, blurred vision, insomnia, vertigo, and nausea are commonly associated with the disease. This review explores the mechanisms and presentations of ocular and central nervous system involvement in acute NE.