PRED-GPCR: GPCR recognition and family classification server

The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention. As the data flow rate from the various genome and proteome projects conti...

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Published inNucleic acids research Vol. 32; no. suppl-2; pp. W380 - W382
Main Authors Papasaikas, P. K., Bagos, P. G., Litou, Z. I., Promponas, V. J., Hamodrakas, S. J.
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.07.2004
Oxford Publishing Limited (England)
Subjects
Internet
Receptors, G-Protein-Coupled - chemistry
Receptors, G-Protein-Coupled - classification
Reproducibility of Results
Sequence Analysis, Protein
Software
User-Computer Interface
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Summary:The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention. As the data flow rate from the various genome and proteome projects continues to grow, so does the need for fast, automated and reliable screening for new members of the various GPCR families. PRED-GPCR is a free Internet service for GPCR recognition and classification at the family level. A submitted sequence or set of sequences, is queried against the PRED-GPCR library, housing 265 signature profile HMMs corresponding to 67 well-characterized GPCR families. Users query the server through a web interface and results are presented in HTML output format. The server returns all single-motif matches along with the combined results for the corresponding families. The service is available online since October 2003 at http://bioinformatics.biol.uoa.gr/PRED-GPCR.
Bibliography:Received February 15, 2004; Revised April 2, 2004; Accepted April 13, 2004
To whom correspondence should be addressed. Tel: +30 210 727 4545 or +30 210 727 4931; Fax: +30 210 727 4742; Email: shamodr@cc.uoa.gr
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The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkh431