Effect of Ivabradine on Heart Failure With Preserved Ejection Fraction

When the ejection fraction is preserved, the effect of afterload is particularly evident and significantly exacerbated at higher pre-loads (2). [...]to normal hearts, the myocardium of heart failure patients may exhibit a flat or negative myocardial relaxation velocity to HR relationship, even at a...

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Bibliographic Details
Published inJournal of the American College of Cardiology Vol. 63; no. 6; pp. 608 - 609
Main Authors Santos, Mário, MD, Leite-Moreira, Adelino F., MD, PhD
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 18.02.2014
Elsevier
Elsevier Limited
Subjects
Antiarythmic agents
Benzazepines - therapeutic use
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiotonic Agents - therapeutic use
Cardiovascular
Cardiovascular system
Drug therapy
Exercise Tolerance - drug effects
Female
Fractions
Heart
Heart failure
Heart Failure - drug therapy
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Internal Medicine
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Pharmacology. Drug treatments
Heart failure
Heart disease
Ivabradine
Cardiovascular disease
Circulatory system
Hemodynamics
Antiarrhythmic agent
Cardiology
Ejection fraction
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Summary:When the ejection fraction is preserved, the effect of afterload is particularly evident and significantly exacerbated at higher pre-loads (2). [...]to normal hearts, the myocardium of heart failure patients may exhibit a flat or negative myocardial relaxation velocity to HR relationship, even at a lower range of HR (3).
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2013.09.064