Inflammation in Complicated Pregnancy and Its Outcome

• Published in: American journal of perinatology Vol. 33; no. 14; p. 1337
• Main Authors: Kalagiri, Ram R, Carder, Timothy, Choudhury, Saiara, Vora, Niraj, Ballard, Amie R, Govande, Vinayak, Drever, Nathan, Beeram, Madhava R, Uddin, M Nasir
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Chemokines - metabolism; Diabetes, Gestational - immunology; Female; Fetal Growth Retardation - immunology; Hormones - metabolism; Humans; Immunity, Cellular; Immunity, Innate; Infant, Newborn; Inflammation - physiopathology; Obesity - immunology; Pre-Eclampsia - immunology; Pregnancy; Pregnancy Complications - immunology; Pregnancy Outcome; Premature Birth - immunology; Toll-Like Receptors - metabolism
• ISSN: 1098-8785
• DOI: 10.1055/s-0036-1582397

Normal pregnancy relies on a careful balance between immune tolerance and suppression. It is known that strict regulation of maternal immune function, in addition to components of inflammation, is paramount to successful pregnancy, and any imbalance between proinflammatory and anti-inflammatory cytokines and chemokines can lead to aberrant inflammation, often seen in complicated pregnancies. Inflammation in complicated pregnancies is directly associated with increased mortality and morbidity of the mother and offspring. Aberrant inflammatory reactions in complicated pregnancies often lead to adverse outcomes, such as spontaneous abortion, preterm labor, intrauterine growth restriction, and fetal demise. The role of inflammation in different stages of normal pregnancy is reviewed, compared, and contrasted with aberrant inflammation in complicated pregnancies. The complications addressed are preterm labor, pregnancy loss, infection, preeclampsia, maternal obesity, gestational diabetes mellitus, autoimmune diseases, and inflammatory bowel disease.  This article examines the role of various inflammatory factors contributing to aberrant inflammation in complicated pregnancies. By understanding the aberrant inflammatory process in complicated pregnancies, novel diagnostic tools and therapeutic interventions for modulating it appropriately can be identified.