Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer

Peripheral blood plasma profiles of circulating microRNA expression were analyzed in patients with prostatic cancer and benign hyperplasia. In prostatic cancer, significant increase in hsa-miR-619-5p and hsa-miR-1184 microRNA expression and significant decrease in hsalet-7b-5p and hsa-let-7c-5p micr...

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Published inBulletin of experimental biology and medicine Vol. 161; no. 1; pp. 108 - 111
Main Authors Knyazev, E. N., Fomicheva, K. A., Mikhailenko, D. S., Nyushko, K. M., Samatov, T. R., Alekseev, B. Ya, Shkurnikov, M. Yu
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2016
Springer
Springer Nature B.V
Subjects
Biomarkers, Tumor - blood
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer diagnosis
Cell Biology
Diagnosis
Diagnosis, Differential
Genes
Health savings accounts
Health screening
Humans
Hyperplasia
Internal Medicine
Laboratory Medicine
Male
MicroRNA
MicroRNAs - blood
Pathology
Prostatic Hyperplasia - blood
Prostatic Hyperplasia - diagnosis
Prostatic Neoplasms - blood
Prostatic Neoplasms - diagnosis
microRNA
microchip analysis
blood plasma
benign prostatic hyperplasia
prostatic cancer
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Summary:Peripheral blood plasma profiles of circulating microRNA expression were analyzed in patients with prostatic cancer and benign hyperplasia. In prostatic cancer, significant increase in hsa-miR-619-5p and hsa-miR-1184 microRNA expression and significant decrease in hsalet-7b-5p and hsa-let-7c-5p microRNA expression were observed. The role of the relationship between the microRNA expression and the activities and functions of host genes with introns encoding these microRNA is discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3357-7