Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study

A series of isoxazoline derivatives were synthesized and investigated for their in vitro inhibitory activity towards human leukocyte elastase, cathepsin G and proteinase 3. A series isoxazoline derivatives (I) were synthesized and investigated for their inhibitory activity toward elastase, cathepsin...

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Published inBioorganic & medicinal chemistry Vol. 3; no. 2; pp. 125 - 128
Main Authors Groutas, William C., Venkataraman, Radhika, Chong, Lee S., Yoder, James E., Epp, Jeffrey B., Stanga, Michael A., Kim, Eun-Hong
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.1995
Subjects
Cathepsin G
Cathepsins - antagonists & inhibitors
Humans
Isoxazoles - chemical synthesis
Isoxazoles - chemistry
Isoxazoles - pharmacology
Kinetics
Leukocyte Elastase
Magnetic Resonance Spectroscopy
Molecular Structure
Myeloblastin
Pancreatic Elastase - antagonists & inhibitors
Protease Inhibitors - chemical synthesis
Protease Inhibitors - chemistry
Protease Inhibitors - pharmacology
Serine Endopeptidases - drug effects
Structure-Activity Relationship
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Summary:A series of isoxazoline derivatives were synthesized and investigated for their in vitro inhibitory activity towards human leukocyte elastase, cathepsin G and proteinase 3. A series isoxazoline derivatives (I) were synthesized and investigated for their inhibitory activity toward elastase, cathepsin G and proteinse 3.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0968-0896
1464-3391
DOI:10.1016/0968-0896(95)00006-3