Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review

Diabetes mellitus (DM) is a widespread metabolic disorder with a yearly 6.7 million deaths worldwide. Several treatment options are available but with common side effects like weight gain, cardiovascular diseases, neurotoxicity, hepatotoxicity, and nephrotoxicity. Therefore, ethnomedicine is gaining...

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Published inFrontiers in pharmacology Vol. 14; p. 1176618
Main Authors Elmi, Gul Rehman, Anum, Kamil, Saleem, Kalsoom, Fareed, Rameesha, Noreen, Sobia, Wei, Haiyan, Chen, Yongxing, Chakraborty, Avirup, Rehman, Masood Ur, Liyuan, Shi, Abbas, Muhammad, Duan, Yongtao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 07.04.2023
Subjects
clinical trail
diabetes
ethnomedicine
outcome
Pharmacology
systematic review
treatment
clinical trail
ethnomedicine
treatment
systematic review
diabetes
outcome
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Summary:Diabetes mellitus (DM) is a widespread metabolic disorder with a yearly 6.7 million deaths worldwide. Several treatment options are available but with common side effects like weight gain, cardiovascular diseases, neurotoxicity, hepatotoxicity, and nephrotoxicity. Therefore, ethnomedicine is gaining the interest of researchers in the treatment of DM. Ethnomedicine works by preventing intestinal absorption and hepatic production of glucose as well as enhancing glucose uptake in muscles and fatty tissues and increasing insulin secretion. A variety of plants have entered clinical trials but very few have gained approval for use. This current study provides an evaluation of such clinical trials. For this purpose, an extensive literature review was performed from a database using keywords like "ethnomedicine diabetes clinical trial", "clinical trials", "clinical trial in diabetes", "diabetes", "natural products in diabetes", "ethno-pharmacological relevance of natural products in diabetes", etc. Clinical trials of 20 plants and natural products were evaluated based on eligibility criteria. Major limitations associated with these clinical trials were a lack of patient compliance, dose-response relationship, and an evaluation of biomarkers with a small sample size and treatment duration. Measures in terms of strict regulations can be considered to achieve quality clinical trials. A specific goal of this systematic review is to discuss DM treatment through ethnomedicine based on recent clinical trials of the past 7 years.
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SourceType-Scholarly Journals-1
This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
Reviewed by: Muhammad Amjad Chaudhary, Pakistan Institute of Medical Sciences (PIMS), Pakistan
These authors have contributed equally to this work
Edited by: Muhammad Hasnat, University of Veterinary and Animal Sciences, Pakistan
Muhammad Asadullah Madni, Islamia University of Bahawalpur, Pakistan
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2023.1176618