Photoacoustic/Ultrasound/Optical Coherence Tomography Evaluation of Melanoma Lesion and Healthy Skin in a Swine Model

• Published in: Sensors (Basel, Switzerland) Vol. 19; no. 12; p. 2815
• Main Authors: Kratkiewicz, Karl, Manwar, Rayyan, Rajabi-Estarabadi, Ali, Fakhoury, Joseph, Meiliute, Jurgita, Daveluy, Steven, Mehregan, Darius, Avanaki, Kamran Mohammad
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.06.2019; MDPI
• Subjects: Animals; Biopsy; cancer imaging; Diagnostic systems; Histology; Lasers; Medical imaging; Melanoma; Melanoma - diagnostic imaging; Melanoma - metabolism; Metastasis; Microscopy; Optical Coherence Tomography; photoacoustic imaging; Photoacoustic Techniques - methods; Skin - diagnostic imaging; Skin - metabolism; Skin cancer; skin imaging; Skin Neoplasms - diagnostic imaging; Skin Neoplasms - metabolism; Swine; swine melanoma model; Tomography, Optical Coherence - methods; Ultrasonic imaging; Ultrasound; Detroit Michigan; skin imaging; optical coherence tomography; photoacoustic imaging; cancer imaging; melanoma; swine melanoma model; ultrasound
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s19122815

The marked increase in the incidence of melanoma coupled with the rapid drop in the survival rate after metastasis has promoted the investigation into improved diagnostic methods for melanoma. High-frequency ultrasound (US), optical coherence tomography (OCT), and photoacoustic imaging (PAI) are three potential modalities that can assist a dermatologist by providing extra information beyond dermoscopic features. In this study, we imaged a swine model with spontaneous melanoma using these modalities and compared the images with images of nearby healthy skin. Histology images were used for validation.