Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Carnosine is a naturally occurring dipeptide and has a scavenging property. The aim of present study was to assess the lipid peroxidation and antioxidant enzymes in association with oxidative stress in cisplatin -...

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Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 25; no. 1; pp. 86 - 91
Main Authors Noori, S., Mahboob, Tabassum
Format Journal Article
LanguageEnglish
Published India Springer-Verlag 2010
Springer Nature B.V
Subjects
Antioxidants
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Chemotherapy
Kidneys
Life Sciences
Lipids
Microbiology
Original
Original Article
Oxidation
Pathology
Rodents
Lipid peroxidation
Oxidative stress
Carnosine
Antioxidant enzymes
Cisplatin
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Summary:Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Carnosine is a naturally occurring dipeptide and has a scavenging property. The aim of present study was to assess the lipid peroxidation and antioxidant enzymes in association with oxidative stress in cisplatin -treated and 10 subsequent doses of carnosine-pretreated rats. 24 male Albino Wistar rats, were randomly divided into four groups (n=6). Group I remains untreated; Group II received Cisplatin (3 mg / kg) for 5 alternate days; Group III received Carnosine (10 mg / kg) for consecutive 10 days; Group IV received Carnosine (10 mg / kg) before administration of Cisplatin (3 mg / kg). The effects of carnosine on cisplatin-induced nephrotoxicity were evaluated by plasma creatinine, urea, malondialdehyde, nitrate; kidney tissue malondialdehyde, 4-HNE, superoxide dismutase and catalase activities. Cisplatin-induced oxidative stress was indicated by increased level of tissue MDA, 4-HNE and decreased level of tissue GSH, SOD and Catalase. Marked elevation of kidney weight and reduced body weight and pathological changes in kidney tissues were also observed in Cisplatin-treated rats. Carnosine reduced these pathological changes and counteracted the deleterious effects of cisplatin. The results divulge the beneficial effect of Carnosine pretreatment with cisplatin in experimental rat model.
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-010-0018-x