The microbiomic signature of hemorrhoids and comparison with associated microbiomes
Hemorrhoids are a common ailment that can cause significant disruptions to one’s daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samp...
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| Published in | Frontiers in microbiology Vol. 15; p. 1329976 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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13.05.2024
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| Abstract | Hemorrhoids are a common ailment that can cause significant disruptions to one’s daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samples from 60 hemorrhoid patients and analyzed the composition and characteristics of microbiomes in hemorrhoids. PCoA results revealed distinct differences between the microbiomes of hemorrhoids, skin-originated microbiomes, and gut microbes, highlighting the complex nature of hemorrhoidal microbiomes. The distribution characteristics of
Staphylococcus
suggest that the skin microbiome influences the microbiome of hemorrhoids. Additionally, we observed higher levels of
Prevotella
in two cases of thrombosed hemorrhoids compared to non-thrombosed hemorrhoids. This finding suggests that
Prevotella
may play a crucial role in the development of thrombosed hemorrhoids. |
|---|---|
| AbstractList | Hemorrhoids are a common ailment that can cause significant disruptions to one’s daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samples from 60 hemorrhoid patients and analyzed the composition and characteristics of microbiomes in hemorrhoids. PCoA results revealed distinct differences between the microbiomes of hemorrhoids, skin-originated microbiomes, and gut microbes, highlighting the complex nature of hemorrhoidal microbiomes. The distribution characteristics of
Staphylococcus
suggest that the skin microbiome influences the microbiome of hemorrhoids. Additionally, we observed higher levels of
Prevotella
in two cases of thrombosed hemorrhoids compared to non-thrombosed hemorrhoids. This finding suggests that
Prevotella
may play a crucial role in the development of thrombosed hemorrhoids. Hemorrhoids are a common ailment that can cause significant disruptions to one's daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samples from 60 hemorrhoid patients and analyzed the composition and characteristics of microbiomes in hemorrhoids. PCoA results revealed distinct differences between the microbiomes of hemorrhoids, skin-originated microbiomes, and gut microbes, highlighting the complex nature of hemorrhoidal microbiomes. The distribution characteristics of Staphylococcus suggest that the skin microbiome influences the microbiome of hemorrhoids. Additionally, we observed higher levels of Prevotella in two cases of thrombosed hemorrhoids compared to non-thrombosed hemorrhoids. This finding suggests that Prevotella may play a crucial role in the development of thrombosed hemorrhoids.Hemorrhoids are a common ailment that can cause significant disruptions to one's daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samples from 60 hemorrhoid patients and analyzed the composition and characteristics of microbiomes in hemorrhoids. PCoA results revealed distinct differences between the microbiomes of hemorrhoids, skin-originated microbiomes, and gut microbes, highlighting the complex nature of hemorrhoidal microbiomes. The distribution characteristics of Staphylococcus suggest that the skin microbiome influences the microbiome of hemorrhoids. Additionally, we observed higher levels of Prevotella in two cases of thrombosed hemorrhoids compared to non-thrombosed hemorrhoids. This finding suggests that Prevotella may play a crucial role in the development of thrombosed hemorrhoids. Hemorrhoids are a common ailment that can cause significant disruptions to one's daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samples from 60 hemorrhoid patients and analyzed the composition and characteristics of microbiomes in hemorrhoids. PCoA results revealed distinct differences between the microbiomes of hemorrhoids, skin-originated microbiomes, and gut microbes, highlighting the complex nature of hemorrhoidal microbiomes. The distribution characteristics of suggest that the skin microbiome influences the microbiome of hemorrhoids. Additionally, we observed higher levels of in two cases of thrombosed hemorrhoids compared to non-thrombosed hemorrhoids. This finding suggests that may play a crucial role in the development of thrombosed hemorrhoids. Hemorrhoids are a common ailment that can cause significant disruptions to one’s daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samples from 60 hemorrhoid patients and analyzed the composition and characteristics of microbiomes in hemorrhoids. PCoA results revealed distinct differences between the microbiomes of hemorrhoids, skin-originated microbiomes, and gut microbes, highlighting the complex nature of hemorrhoidal microbiomes. The distribution characteristics of Staphylococcus suggest that the skin microbiome influences the microbiome of hemorrhoids. Additionally, we observed higher levels of Prevotella in two cases of thrombosed hemorrhoids compared to non-thrombosed hemorrhoids. This finding suggests that Prevotella may play a crucial role in the development of thrombosed hemorrhoids. |
| Author | Wang, Mingyu Su, Wenya Li, Ling Xu, Hai Wang, Yuquan Shen, Wenlong Liu, Zhiqiang Wang, Yihua |
| AuthorAffiliation | 1 Department of Anorectal Surgery, Qilu Hospital of Shandong University (Qingdao) , Shandong , China 2 State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University , Jinan, Qingdao , China |
| AuthorAffiliation_xml | – name: 2 State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University , Jinan, Qingdao , China – name: 1 Department of Anorectal Surgery, Qilu Hospital of Shandong University (Qingdao) , Shandong , China |
| Author_xml | – sequence: 1 givenname: Yuquan surname: Wang fullname: Wang, Yuquan – sequence: 2 givenname: Wenya surname: Su fullname: Su, Wenya – sequence: 3 givenname: Zhiqiang surname: Liu fullname: Liu, Zhiqiang – sequence: 4 givenname: Yihua surname: Wang fullname: Wang, Yihua – sequence: 5 givenname: Ling surname: Li fullname: Li, Ling – sequence: 6 givenname: Hai surname: Xu fullname: Xu, Hai – sequence: 7 givenname: Mingyu surname: Wang fullname: Wang, Mingyu – sequence: 8 givenname: Wenlong surname: Shen fullname: Shen, Wenlong |
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| Keywords | microbial community structure thrombosed hemorrhoid bacterial infection microbiomic hemorrhoids |
| Language | English |
| License | Copyright © 2024 Wang, Su, Liu, Wang, Li, Xu, Wang and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| References | Burkitt (ref4) 1972; 2 Takahashi (ref22) 2016; 93 Adler (ref1) 1905 Lundberg (ref15) 2013; 10 Aigner (ref2) 2009; 24 Steen (ref21) 2019; 13 Feyen (ref7) 2022; 194 Liu (ref12) 2023; 9 Mallick (ref16) 2021; 17 Zhang (ref25) 2019; 98 Riss (ref20) 2012; 27 Bokulich (ref3) 2018; 6 Yuan (ref24) 2023; 184 Thomson (ref23) 1975; 68 Chawla (ref5) 1989; 1 Jeffery (ref10) 2012; 61 Chung (ref9001) 2004; 34 Parthasarathy (ref19) 2016; 150 Lohsiriwat (ref14) 2012; 18 Feng (ref6) 2023; 134 Palumbo (ref18) 2023; 12 Nishino (ref17) 2018; 53 Loder (ref13) 1994; 81 Halverson (ref9) 2007; 20 Johanson (ref11) 1990; 98 Haas (ref8) 1984; 27 |
| References_xml | – volume: 150 start-page: 367 year: 2016 ident: ref19 article-title: Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation publication-title: Gastroenterology doi: 10.1053/j.gastro.2015.10.005 – volume: 93 start-page: 174 year: 2016 ident: ref22 article-title: Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn's disease publication-title: J. Gastroenterol. Hepatol. doi: 10.1159/000444541 – volume: 68 start-page: 574 year: 1975 ident: ref23 article-title: The nature and cause of haemorrhoids publication-title: Proc. R. Soc. Med. doi: 10.1177/003591577506800916 – volume: 18 start-page: 2009 year: 2012 ident: ref14 article-title: Hemorrhoids: from basic pathophysiology to clinical management publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v18.i17.2009 – volume: 10 start-page: 999 year: 2013 ident: ref15 article-title: Practical innovations for high-throughput amplicon sequencing publication-title: Nat. Methods doi: 10.1038/nmeth.2634 – volume: 27 start-page: 442 year: 1984 ident: ref8 article-title: The pathogenesis of hemorrhoids publication-title: Dis. Colon Rectum doi: 10.1007/bf02555533 – volume: 81 start-page: 946 year: 1994 ident: ref13 article-title: Hemorrhoids-pathology, pathophysiology and etiology publication-title: Brit. J. Surg. doi: 10.1002/bjs.1800810707 – volume: 134 start-page: lxad221 year: 2023 ident: ref6 article-title: Gut microbial signatures of patients with primary hepatocellular carcinoma and their healthy first-degree relatives publication-title: J. Appl. Microbiol. doi: 10.1093/jambio/lxad221 – volume: 2 start-page: 556 year: 1972 ident: ref4 article-title: Varicose veins, deep vein-thrombosis, and hemorrhoids-epidemiology and suggested etiology publication-title: Brit. Med. J. doi: 10.1136/bmj.2.5813.556 – volume: 13 start-page: 3126 year: 2019 ident: ref21 article-title: High proportions of bacteria and archaea across most biomes remain uncultured publication-title: ISME J. doi: 10.1038/s41396-019-0484-y – volume: 6 start-page: 90 year: 2018 ident: ref3 article-title: Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2’s q2-feature-classifier plugin publication-title: Microbiome doi: 10.1186/s40168-018-0470-z – volume: 1 start-page: 725 year: 1989 ident: ref5 article-title: Anorectal varices, hemorrhoids, and portal-hypertension publication-title: Lancet doi: 10.1016/S0140-6736(89)92238-1 – volume: 98 start-page: 380 year: 1990 ident: ref11 article-title: The prevalence of hemorrhoids and chronic constipation publication-title: Gastroenterology doi: 10.1016/0016-5085(90)90828-o – volume: 194 start-page: 266 year: 2022 ident: ref7 article-title: Embolization of hemorrhoidal arteries: a novel endovascular therapy option for the treatment of hemorrhoidal disease publication-title: RöFo doi: 10.1055/a-1662-5487 – volume: 17 start-page: e1009442 year: 2021 ident: ref16 article-title: Multivariable association discovery in population-scale meta-omics studies publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1009442 – volume: 24 start-page: 105 year: 2009 ident: ref2 article-title: Revised morphology and hemodynamics of the anorectal vascular plexus: impact on the course of hemorrhoidal disease publication-title: Int. J. Color. Dis. doi: 10.1007/s00384-008-0572-3 – volume: 27 start-page: 215 year: 2012 ident: ref20 article-title: The prevalence of hemorrhoids in adults publication-title: Int. J. Color. Dis. doi: 10.1007/s00384-011-1316-3 – volume: 184 start-page: 106373 year: 2023 ident: ref24 article-title: Characteristics of the Cajal interstitial cells and intestinal microbiota in children with refractory constipation publication-title: Microb. Pathog. doi: 10.1016/j.micpath.2023.106373 – volume: 20 start-page: 77 year: 2007 ident: ref9 article-title: Hemorrhoids publication-title: Clin. Colon. Rect. Surg. doi: 10.1055/s-2007-977485 – volume: 34 start-page: 107 year: 2004 ident: ref9001 article-title: Endoglin (CD105) expression in the development of haemorrhoids publication-title: Europ. J. Clin. Invest. doi: 10.1111/j.1365-2362.2004.01305.x – start-page: 193 year: 1905 ident: ref1 article-title: Internal and external hemorrhoids—with special reference to their treatment publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.1905.92500300025001g – volume: 98 start-page: e14441 year: 2019 ident: ref25 article-title: Somatosensory stimulation treatments for postoperative analgesia of mixed hemorrhoids: protocol for a systematic review and network meta-analysis publication-title: Medicine doi: 10.1097/MD.0000000000014441 – volume: 61 start-page: 997 year: 2012 ident: ref10 article-title: An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota publication-title: Gut doi: 10.1136/gutjnl-2011-301501 – volume: 12 start-page: 2198 year: 2023 ident: ref18 article-title: Altered gut microbic flora and haemorrhoids: could they have a possible relationship? publication-title: J. Clin. Med. doi: 10.3390/jcm12062198 – volume: 53 start-page: 95 year: 2018 ident: ref17 article-title: Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease publication-title: J. Gastroenterol. doi: 10.1007/s00535-017-1384-4 – volume: 9 start-page: e20328 year: 2023 ident: ref12 article-title: Alterations of gut microbiota and metabolome in early chronic kidney disease patients complicated with hyperuricemia publication-title: Heliyon doi: 10.1016/j.heliyon.2023.e20328 |
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| Snippet | Hemorrhoids are a common ailment that can cause significant disruptions to one’s daily life. While some researchers have speculated about a potential link... Hemorrhoids are a common ailment that can cause significant disruptions to one's daily life. While some researchers have speculated about a potential link... |
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| SubjectTerms | bacterial infection hemorrhoids microbial community structure Microbiology microbiomic thrombosed hemorrhoid |
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| Title | The microbiomic signature of hemorrhoids and comparison with associated microbiomes |
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