Evaluation of the anti-proliferative activity of violacein, a natural pigment of bacterial origin, in urinary bladder cancer cell lines

Violacein is a natural pigment, a pyrrolidone, and a bisindole derived from the condensation of two tryptophan molecules, which gives a blue violet color to several gram-negative violacein-producing bacteria. Violacein production provides a competitive advantage against antagonistic species or preda...

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Bibliographic Details
Published inOncology letters Vol. 23; no. 4; p. 132
Main Authors Neroni, Bruna, Zingaropoli, Maria Antonella, Radocchia, Giulia, Ciardi, Maria Rosa, Mosca, Luciana, Pantanella, Fabrizio, Schippa, Serena
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.04.2022
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects
Analysis
Antibodies
Antifungal agents
Apoptosis
Bladder cancer
Cancer
Cancer therapies
Cell culture
Cell cycle
Cell growth
Chemotherapy
Cytotoxicity
Ethylenediaminetetraacetic acid
Health aspects
Medical prognosis
Oncology
Penicillin
Polyamines
apoptosis
anti-proliferative activity
violacein
bladder cancer
caspase-3
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Summary:Violacein is a natural pigment, a pyrrolidone, and a bisindole derived from the condensation of two tryptophan molecules, which gives a blue violet color to several gram-negative violacein-producing bacteria. Violacein production provides a competitive advantage against antagonistic species or predators. In addition, the compound has antibacterial, antifungal, antiviral, and antioxidant activities. Several studies on colon, breast, and head and neck cancer lines have already demonstrated the anti-proliferative potential of violacein. Bladder cancer is one of the most common types of cancer in urology. The therapeutic approach is mainly based on surgery, chemotherapy, and immunotherapy. The aim of the present study was to evaluate the anti-proliferative activity of violacein against the human bladder cancer cell lines, HTB4 (T24) and HTB9 (5637), using low-grade and high-grade transitional cell carcinoma models, respectively, which has never been assayed before. For this purpose, the potential violacein anti-proliferative effect on T24 and 5637 cells was evaluated by studying the cell viability, proliferation, cell cycle, and caspase-3 activation. The results showed that violacein had anti-proliferative activity in the two cell lines, which was greater for the second-stage bladder cancer cell line (5637), and a different mode of action against the two cell lines.
Bibliography:Contributed equally
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2022.13252