Research progress of E3 ubiquitin ligase regulating biological behavior of human placental trophoblast cells

E3 ubiquitin ligases are important components of the ubiquitin protease system. This family includes many proteins, which can catalyze the ubiquitination of a variety of protein substrates and promote the degradation of them by the proteasome system. Recent studies have shown that E3 ubiquitin ligas...

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Published inFrontiers in endocrinology (Lausanne) Vol. 14; p. 1124041
Main Authors Feng, Jun, Yin, Huimei, Baturuhu, Dai, Yonghui, Dai, Fuxiao, Xu, Junjun, Chen, Zhili, Liu, Yanyan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 14.04.2023
Subjects
apoptosis
E3 ubiquitin ligase
Endocrinology
Female
human trophoblast cells
Humans
in vitro migration
invasiveness
Placenta - metabolism
Pregnancy
proliferation and differentiation
Trophoblasts - metabolism
Ubiquitin - metabolism
Ubiquitin-Protein Ligases - genetics
Ubiquitination
in vitro migration
human trophoblast cells
invasiveness
proliferation and differentiation
apoptosis
E3 ubiquitin ligase
pregnancy complications
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Summary:E3 ubiquitin ligases are important components of the ubiquitin protease system. This family includes many proteins, which can catalyze the ubiquitination of a variety of protein substrates and promote the degradation of them by the proteasome system. Recent studies have shown that E3 ubiquitin ligase plays a key role in the process of fetal development and placental formation. It affects the biological behavior of placental trophoblast cells, leading to a series of pregnancy complications that threaten mothers and babies greatly. This review focuses on the regulation, target and mechanism of E3 ubiquitin ligase on the biological behavior of human placental trophoblast cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Edited by: Honglin Li, Augusta University, United States
Reviewed by: Zongzhi Yin, First Affiliated Hospital of Anhui Medical University, China; Heng Yin, Hubei Maternal and Child Health Hospital, China; Rongzhen Jiang, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, China
This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2023.1124041