Immunization of Domestic Ducks with Live Nonpathogenic H5N3 Influenza Virus Prevents Shedding and Transmission of Highly Pathogenic H5N1 Virus to Chickens

Wild ducks are known to be able to carry avian influenza viruses over long distances and infect domestic ducks, which in their turn infect domestic chickens. Therefore, prevention of virus transmission between ducks and chickens is important to control the spread of avian influenza. Here we used a l...

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Published inViruses Vol. 10; no. 4; p. 164
Main Authors Gambaryan, Alexandra, Gordeychuk, Ilya, Boravleva, Elizaveta, Lomakina, Natalia, Kropotkina, Ekaterina, Lunitsin, Andrey, Klenk, Hans-Dieter, Matrosovich, Mikhail
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 31.03.2018
MDPI
Subjects
Aerosols
Animals
Antibodies
Aquatic birds
Avian flu
Bird migration
Disease
Eggs
Feces
Genes
H5N1
Immunization
Infections
influenza virus A
Laboratories
Mortality
Oral administration
Poultry
poultry vaccine
Proteins
Tissue culture
transmission and environmental control
Vaccines
Viruses
Waterfowl
Russia
influenza virus A
H5N1
poultry vaccine
transmission and environmental control
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Summary:Wild ducks are known to be able to carry avian influenza viruses over long distances and infect domestic ducks, which in their turn infect domestic chickens. Therefore, prevention of virus transmission between ducks and chickens is important to control the spread of avian influenza. Here we used a low pathogenic wild aquatic bird virus A/duck/Moscow/4182/2010 (H5N3) for prevention of highly pathogenic avian influenza virus (HPAIV) transmission between ducks and chickens. We first confirmed that the ducks orally infected with H5N1 HPAIV A/chicken/Kurgan/3/2005 excreted the virus in feces. All chickens that were in contact with the infected ducks became sick, excreted the virus, and died. However, the ducks orally inoculated with 10⁴ 50% tissue culture infective doses of A/duck/Moscow/4182/2010 and challenged 14 to 90 days later with H5N1 HPAIV did not excrete the challenge virus. All contact chickens survived and did not excrete the virus. Our results suggest that low pathogenic virus of wild aquatic birds can be used for prevention of transmission of H5N1 viruses between ducks and chickens.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v10040164