Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: the Ariel Project for the Prevention of Transmission of HIV from Mother to Infant

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Published inJournal of Virology Vol. 73; no. 5; pp. 3975 - 3985
Main Authors Wilson, C C, Brown, R C, Korber, B T, Wilkes, B M, Ruhl, D J, Sakamoto, D, Kunstman, K, Luzuriaga, K, Hanson, I C, Widmayer, S M, Wiznia, A, Clapp, S, Ammann, A J, Koup, R A, Wolinsky, S M, Walker, B D
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.05.1999
Subjects
AIDS/HIV
Base Sequence
Cell Line, Transformed
DNA, Viral
Epitopes, T-Lymphocyte - immunology
Female
Genetic Variation
Histocompatibility Antigens Class I - immunology
HIV Infections - immunology
HIV Infections - transmission
HIV Infections - virology
HIV-1 - classification
HIV-1 - genetics
HIV-1 - immunology
Human immunodeficiency virus 1
Humans
Infectious Disease Transmission, Vertical
Molecular Sequence Data
Pathogenesis and Immunity
Pregnancy
Pregnancy Complications, Infectious - immunology
Pregnancy Complications, Infectious - virology
T-Lymphocytes, Cytotoxic - immunology
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Corresponding author. Mailing address for Steven M. Wolinsky: Northwestern University School of Medicine, 303 E. Chicago Ave., Chicago, IL 60611. Phone: (312) 908-5210. Fax: (312) 908-4588. E-mail: s-wolinsky@nwu.edu. Mailing address for Bruce D. Walker: AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Fruit Street, Boston, Massachusetts 02114. Phone: (617) 724-8332. Fax: (617) 726-4691. E-mail: bwalker@helix.mgh.harvard.edu.
Present address: Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262.
Present address: University of Texas Southwestern Medical School, Dallas, Tex.
The Ariel Project is a Pediatric AIDS Foundation-sponsored project. Clinical site principal investigators include S.M.W., I.C.H., A.W., and K.L., as well as Russell B. Van Dyke (Tulane University of Medicine, New Orleans, La.), Arlene Bardeguez (UMD-New Jersey Medical School, Newark, N.J.), and Richard R. Viscarello (Maternal Fetal Care, P.C., Stamford, Conn.). Core investigators include B.T.K., B.D.W., and S.M.W., as well as David Ho and Rick Koup (Aaron Diamond AIDS Research Center, New York, N.Y.), Irvin Chen and Paul Krogstad, (University of California, Los Angeles), and James Mullins (University of Washington, Seattle). A.J.A. and S.C. are study coordinators. The Data Management Center is coordinated by B.T.K., David McDonald, and Robert Funkhouser.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.73.5.3975-3985.1999