The effect of ticlopidine administration to humans on the binding of adenosine diphosphate to blood platelets
Administration of Ticlopidine to human volunteers resulted in a prolonged bleeding time and decreased or absent aggregation of platelets with collagen and epinephrine. Adenosine diphosphate (ADP) induced platelet aggregation was initiated by a normal shape change, but the rate of the first wave of a...
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| Published in | Thrombosis research Vol. 17; no. 1; pp. 19 - 27 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
1980
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Administration of Ticlopidine to human volunteers resulted in a prolonged bleeding time and decreased or absent aggregation of platelets with collagen and epinephrine. Adenosine diphosphate (ADP) induced platelet aggregation was initiated by a normal shape change, but the rate of the first wave of aggregation had decreased. The second wave of aggregation was absent. ADP-binding to platelets of volunteers, consisted of two classes of binding sites:one with high affinity and one with low affinity, giving a curvilinear and a linear part in a concentration dependency curve. After Ticlopidine, the low affinity part of the curve had disappeared. Evidence will be presented that this is a specific Ticlopidine effect. |
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| AbstractList | Administration of Ticlopidine to human volunteers resulted in a prolonged bleeding time and decreased or absent aggregation of platelets with collagen and epinephrine. Adenosine diphosphate (ADP) induced platelet aggregation was initiated by a normal shape change, but the rate of the first wave of aggregation had decreased. The second wave of aggregation was absent. ADP-binding to platelets of volunteers, consisted of two classes of binding sites:one with high affinity and one with low affinity, giving a curvilinear and a linear part in a concentration dependency curve. After Ticlopidine, the low affinity part of the curve had disappeared. Evidence will be presented that this is a specific Ticlopidine effect. |
| Author | Schiphorst, Marion E. Sixma, Jan J. Lips, Joost P.M. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7376129$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1113/jphysiol.1975.sp011123 10.1016/0049-3848(78)90195-0 10.1056/NEJM197608192950805 10.1172/JCI108872 10.1016/0005-2787(69)90003-3 10.1016/S0140-6736(77)92767-2 10.1016/0049-3848(78)90012-9 10.1182/blood.V34.2.204.204 10.1111/j.1365-2141.1972.tb08801.x |
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| References_xml | – start-page: 280 year: 1976 ident: BIB15 article-title: Ticlopidine, a new inhibitor of platelet aggreqation and its antithrombotic effect publication-title: Abstract of the 16th International Congress of Hematology contributor: fullname: Parak – volume: 58 start-page: 731 year: 1976 ident: BIB2 article-title: Homocystine induced arteriosclerosis publication-title: The role of endothelial cell injury and platelet response in its genesis contributor: fullname: Scott – volume: 186 start-page: 254 year: 1969 ident: BIB10 article-title: Adenine nucleotide metabolism of blood platelets. VI Subcellular localization of nucleotide pools with different functions in the platelet release reaction publication-title: Biochim. Biophys. Acta contributor: fullname: Storm – volume: 251 start-page: 803 year: 1975 ident: BIB11 article-title: Binding of adenosine diphosphate to intact human platelets publication-title: J. Physiol. contributor: fullname: Feinberg – volume: 13 start-page: 901 year: 1978 ident: BIB8 article-title: Effect of Ticlopidine and acetyl salicylic acid on generation of prostaglandin I publication-title: Thromb. Res. contributor: fullname: Abiko – volume: II start-page: 532 year: 1973 ident: BIB4 article-title: Treatment of atherosclerosis and thrombosis with aspirin publication-title: Lancet contributor: fullname: Wood – volume: 13 start-page: 245 year: 1978 ident: BIB7 article-title: Ticlopidine - An antiplatelet drug: Effects in human volunteers publication-title: Thromb. Res. contributor: fullname: Shuttleworth – volume: 34 start-page: 204 year: 1969 ident: BIB9 article-title: The standardized normal Ivy bleeding time and its prolongation by aspirin publication-title: Blood contributor: fullname: Rppaport – volume: 19 start-page: 420 year: 1976 ident: BIB1 article-title: The pathogenesis of atherosclerosis publication-title: New Engl. J. Med. contributor: fullname: Glomset – volume: 60 start-page: 1191 year: 1977 ident: BIB3 article-title: The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits publication-title: J. Clin. Invest. contributor: fullname: Spaet – volume: 22 start-page: 205 year: 1972 ident: BIB13 article-title: Albumin density gradient separation and washing of platelets and the study of platelet coagulant activities publication-title: Brit. J. Hematol. contributor: fullname: Walsh – volume: 18 start-page: 485 year: 1975 ident: BIB6 article-title: Contribution à l'étude pharmacologique de thiénopyridines et d'analogues furanniques publication-title: Eur. J. Med. Chem. contributor: fullname: Ferrand – volume: I start-page: 1216 year: 1977 ident: BIB5 article-title: Prostacyclin and atherosclerosis in rats publication-title: Lancet contributor: fullname: De Gaetano – volume: 38 start-page: 64 year: 1977 ident: BIB14 article-title: Pharmacological evaluation of Ticlopidine, a novel inhibitor of platelet function publication-title: Thromb. Haemost. contributor: fullname: Strachan – volume: II start-page: 532 year: 1973 ident: 10.1016/0049-3848(80)90290-X_BIB4 article-title: Treatment of atherosclerosis and thrombosis with aspirin publication-title: Lancet contributor: fullname: Wood – volume: 251 start-page: 803 year: 1975 ident: 10.1016/0049-3848(80)90290-X_BIB11 article-title: Binding of adenosine diphosphate to intact human platelets publication-title: J. Physiol. doi: 10.1113/jphysiol.1975.sp011123 contributor: fullname: Born – volume: 13 start-page: 901 year: 1978 ident: 10.1016/0049-3848(80)90290-X_BIB8 article-title: Effect of Ticlopidine and acetyl salicylic acid on generation of prostaglandin I2-like substance in rat arterial tissue publication-title: Thromb. Res. doi: 10.1016/0049-3848(78)90195-0 contributor: fullname: Ashida – ident: 10.1016/0049-3848(80)90290-X_BIB12 – volume: 19 start-page: 420 year: 1976 ident: 10.1016/0049-3848(80)90290-X_BIB1 article-title: The pathogenesis of atherosclerosis publication-title: New Engl. J. Med. doi: 10.1056/NEJM197608192950805 contributor: fullname: Ross – volume: 60 start-page: 1191 year: 1977 ident: 10.1016/0049-3848(80)90290-X_BIB3 article-title: The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits publication-title: J. Clin. Invest. doi: 10.1172/JCI108872 contributor: fullname: Freedman – volume: 58 start-page: 731 year: 1976 ident: 10.1016/0049-3848(80)90290-X_BIB2 article-title: Homocystine induced arteriosclerosis contributor: fullname: Harker – volume: 186 start-page: 254 year: 1969 ident: 10.1016/0049-3848(80)90290-X_BIB10 article-title: Adenine nucleotide metabolism of blood platelets. VI Subcellular localization of nucleotide pools with different functions in the platelet release reaction publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2787(69)90003-3 contributor: fullname: Holmsen – volume: 18 start-page: 485 year: 1975 ident: 10.1016/0049-3848(80)90290-X_BIB6 article-title: Contribution à l'étude pharmacologique de thiénopyridines et d'analogues furanniques publication-title: Eur. J. Med. Chem. contributor: fullname: Podesta – volume: I start-page: 1216 year: 1977 ident: 10.1016/0049-3848(80)90290-X_BIB5 article-title: Prostacyclin and atherosclerosis in rats publication-title: Lancet doi: 10.1016/S0140-6736(77)92767-2 contributor: fullname: Villa – volume: 13 start-page: 245 year: 1978 ident: 10.1016/0049-3848(80)90290-X_BIB7 article-title: Ticlopidine - An antiplatelet drug: Effects in human volunteers publication-title: Thromb. Res. doi: 10.1016/0049-3848(78)90012-9 contributor: fullname: O'Brien – start-page: 280 year: 1976 ident: 10.1016/0049-3848(80)90290-X_BIB15 article-title: Ticlopidine, a new inhibitor of platelet aggreqation and its antithrombotic effect contributor: fullname: Abiko – volume: 38 start-page: 64 year: 1977 ident: 10.1016/0049-3848(80)90290-X_BIB14 article-title: Pharmacological evaluation of Ticlopidine, a novel inhibitor of platelet function publication-title: Thromb. Haemost. contributor: fullname: Johnson – volume: 34 start-page: 204 year: 1969 ident: 10.1016/0049-3848(80)90290-X_BIB9 article-title: The standardized normal Ivy bleeding time and its prolongation by aspirin publication-title: Blood doi: 10.1182/blood.V34.2.204.204 contributor: fullname: Mielke – volume: 22 start-page: 205 year: 1972 ident: 10.1016/0049-3848(80)90290-X_BIB13 article-title: Albumin density gradient separation and washing of platelets and the study of platelet coagulant activities publication-title: Brit. J. Hematol. doi: 10.1111/j.1365-2141.1972.tb08801.x contributor: fullname: Walsh |
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| SubjectTerms | Adenosine Diphosphate - metabolism Adenosine Diphosphate - pharmacology ADP-receptors Binding Sites Blood Coagulation Tests Blood Platelets - metabolism Collagen - pharmacology Epinephrine - pharmacology Human platelets Humans Male Platelet Aggregation platelet aggregation inhibitors Prostaglandins E - pharmacology Pyridines - administration & dosage Thiophenes - administration & dosage Ticlopidine |
| Title | The effect of ticlopidine administration to humans on the binding of adenosine diphosphate to blood platelets |
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