The effect of herbal medicine in innate immunity to Candida albicans

( ) is an opportunistic pathogenic fungus that often causes mucosal and systemic infections. Several pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), have been implicated in the host recognition of . These PRRs recognize the pathogen-associ...

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Published inFrontiers in immunology Vol. 14; p. 1096383
Main Authors Bao, Meng-Yuan, Li, Ming, Bu, Qing-Ru, Yang, Yue, Song, Hang, Wang, Chang-Zhong, Wang, Tian-Ming, Li, Ning
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.03.2023
Subjects
Candida albicans
herbal medicine
Immunology
immunoregulation
innate immune cells
pattern recognition receptors
Candida albicans
pattern recognition receptors
immunoregulation
innate immune cells
herbal medicine
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Summary:( ) is an opportunistic pathogenic fungus that often causes mucosal and systemic infections. Several pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), have been implicated in the host recognition of . These PRRs recognize the pathogen-associated molecular patterns (PAMPs) of to activate innate immune cells, thereby rapidly inducing various inflammatory responses by activating intracellular signaling cascades. Herbal medicine and its active components deserve priority development due to their low toxicity and high antibacterial, antiviral and antifungal activities. This review discussed the activities of herbal compounds against and their related mechanisms, especially their regulatory role on innate immune cells such as neutrophils, macrophages, and dendritic cells (DCs) implicated in infections. Our work aims to find new therapeutic drugs and targets to prevent and treat diseases caused by infection with the mechanisms by which this fungus interacts with the innate immune response.
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This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
Edited by: Sha Lu, Sun Yat-Sen Memorial Hospital, China
Reviewed by: Zi Li, Guangzhou Medical University, China; Mira Edgerton, University at Buffalo, United States
These authors have contributed equally to this work
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1096383