Cathepsins in oral diseases: mechanisms and therapeutic implications

Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. Findings regarding their functions in human physiological processes and...

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Published inFrontiers in immunology Vol. 14; p. 1203071
Main Authors Jiang, Hao, Dong, Zuoxiang, Xia, Xiaomin, Li, Xue
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.06.2023
Subjects
Apoptosis - physiology
Bone Matrix
cathepsin
Cathepsins
Humans
Immunity, Innate
Immunology
inflammation
molecular mechanism
Mouth Diseases - therapy
oral diseases
oral diseases treatment
molecular mechanism
oral diseases
oral diseases treatment
cathepsin
inflammation
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Summary:Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. Findings regarding their functions in human physiological processes and disorders have drawn extensive attention. In this review, we will focus on the relationship between cathepsins and oral diseases. We highlight the structural and functional properties of cathepsins related to oral diseases, as well as the regulatory mechanisms in tissue and cells and their therapeutic uses. Elucidating the associated mechanism between cathepsins and oral diseases is thought to be a promising strategy for the treatment of oral diseases and may be a starting point for further studies at the molecular level.
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Edited by: Luiz Eduardo Baggio Savio, Federal University of Rio de Janeiro, Brazil
Reviewed by: Ivarne L. S. Tersariol, Federal University of São Paulo, Brazil; Emmanuelle Liaudet-Coopman, Institut National de la Santé et de la Recherche Médicale (INSERM), France
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1203071