Early-life microbiota-immune homeostasis

As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions in cases of dysbiosis. Of particular importance, ar...

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Published inFrontiers in immunology Vol. 14; p. 1266876
Main Authors Reynolds, Hayley M, Bettini, Matthew L
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 23.10.2023
Subjects
Dysbiosis
early-life
fecal microbiota transplant
Gastrointestinal Microbiome
gut microbiota
Homeostasis
Humans
Immunology
Infant, Newborn
Microbiota
prebiotics
probiotics
Probiotics - therapeutic use
early-life
fecal microbiota transplant
prebiotics
immune homeostasis
gut microbiota
dysbiosis
probiotics
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Summary:As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions in cases of dysbiosis. Of particular importance, are alterations to intestinal microbiota occurring within the critical neonatal window, during which the immune system is highly vulnerable to environmental exposures. This review will highlight recent literature concerning mechanisms of early-life microbiota-immune homeostasis as well as discuss the potential for therapeutics in restoring dysbiosis in early life.
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Reviewed by: Gema Mendez Lagares, University of California, Davis, United States
Edited by: Thomas Gensollen, UMR5089 Institut de Pharmacologie et de Biologie Structurale (IPBS), France
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1266876