A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study

• Published in: Frontiers in endocrinology (Lausanne) Vol. 14; p. 1187212
• Main Authors: Wu, Shenghao, Wu, Yanhong, Fang, Lizi, Zhao, Junzhao, Cai, Yaoyao, Xia, Weiting
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.06.2023
• Subjects: Adult; Biomarkers; Blood Glucose - analysis; Body Mass Index; Cross-Sectional Studies; Endocrinology; Glucose; Humans; Insulin Resistance; Male; NHANES; Nutrition Surveys; Testosterone; triglyceride glucose-body mass index; Triglycerides; TyG-BMI; TyG-BMI; Insulin resistance; NHANES; testosterone; triglyceride glucose-body mass index
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2023.1187212

Insulin resistance (IR) is closely related to the decline or deficiency of testosterone in males. Triglyceride glucose-body mass (TyG-BMI) is considered to be a novel indicator of IR. We conducted this analysis to investigate the association between TyG-BMI and male testosterone, and to explore whether its ability to predict testosterone deficiency is superior to HOMA-IR and TyG. This was a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES, 2011-2016). The TyG-BMI index was calculated from serum triglyceride, fasting plasma glucose and BMI. The association of TyG-BMI with male testosterone was estimated by weighted multivariable regression. We included 3394 participants for the final analysis. After adjusting for confounders, TyG-BMI was found to show an independent negative association with testosterone (β=-1.12, 95%CI: -1.50, -0.75, P<0.0001). Multivariate-adjusted beta also showed testosterone levels were significantly lower in the two highest TyG-BMI group (Q3, Q4) compared to the lowest group (Q1). Similar results were seen in all of the subgroup populations by stratified analysis (all P-interaction >0.05). Furthermore, ROC curve analysis indicated that the area under the curve of TyG-BMI index (0.73, 95% CI: 0.71, 0.75) was larger than that of HOMA-IR index (0.71, 95% CI: 0.69, 0.73) and TyG index (0.66, 95% CI: 0.64, 0.68). Our result suggested a negative association between TyG-BMI index and testosterone in adult males. The predictability of the TyG-BMI index for testosterone deficiency is better than that of HOMA-IR index and TyG index.