Peptides and Peptidomimetics for Antimicrobial Drug Design

The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial p...

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Bibliographic Details
Published inPharmaceuticals (Basel, Switzerland) Vol. 8; no. 3; pp. 366 - 415
Main Authors Mojsoska, Biljana, Jenssen, Håvard
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.07.2015
MDPI
Subjects
Antibiotics
Antimicrobial agents
antimicrobial peptides
mechanism of action
Medical research
Peptides
peptidomimetics
Review
Studies
mechanism of action
peptidomimetics
antimicrobial peptides
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Summary:The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial properties are presented. A brief discussion of the mechanisms of action of different antimicrobials as well as the development of bacterial resistance towards antimicrobial peptides follows. Finally, current efforts on novel design strategies and peptidomimetics are introduced to illustrate the importance of antimicrobial peptide research in the development of future antibiotics.
Bibliography:ObjectType-Article-2
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ISSN:1424-8247
1424-8247
DOI:10.3390/ph8030366