State-of-the-art in fast liquid chromatography–mass spectrometry for bio-analytical applications

• Published in: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 927; pp. 3 - 21
• Main Authors: Núñez, Oscar, Gallart-Ayala, Héctor, Martins, Claudia P.B., Lucci, Paolo, Busquets, Rosa
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.05.2013
• Subjects: Animals; Bio-analysis; Biomarkers - analysis; Chromatography; Chromatography, Liquid - methods; Cleaning; Column packings; cost effectiveness; Extraction; high performance liquid chromatography; High resolution mass spectrometry; Humans; Liquid chromatography; Mass spectrometry; MIP and RAM technology; Molecular Imprinting; On-line SPE; particle size; polymers; Separation; Solid Phase Extraction; State of the art; Tandem Mass Spectrometry - methods; turbulent flow; Turbulent flow chromatography; UHPLC column technology; ultra-performance liquid chromatography; On-line SPE; FDA; CBA; LLE; Turbulent flow chromatography; SBSE; Bio-analysis; MSn; ISRP; APCI; SCID; IT-TOF; ATCA; NNAL; SRM; ADS; PRS; TFC; HRMS; SPME; PPT; HETP; ESI; UHPLC; LSD; HILIC; MIP and RAM technology; AIF; RSD; MS; High resolution mass spectrometry; HSS; MISBSE; LOQ; UHPLC column technology; NIP; MIP; PE; APPI; FWHM; API; RAM

► State-of-the-art in fast LC–MS bioanalytical applications is presented. ► Main problems in the sample treatment and LC–MS analysis are discussed. ► On-line SPE, MIPs, RAM and TFC are addressed with relevant applications. ► Novel applications of sub-2μm and porous shell columns are discussed. ► Nov...