Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives
This work explores the biological evaluation of novel cyanomethyl vinyl ether derivatives as antiproliferative agents. Tubulin, crucial to microtubule structure and function, is a target for cancer therapies. cytotoxicity assessments revealed significant activity in SKOV3 ovarian carcinoma cells and...
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Published in | Frontiers in pharmacology Vol. 15; p. 1344042 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
04.03.2024
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Subjects | |
Online Access | Get full text |
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Summary: | This work explores the biological evaluation of novel cyanomethyl vinyl ether derivatives as antiproliferative agents. Tubulin, crucial to microtubule structure and function, is a target for cancer therapies.
cytotoxicity assessments revealed significant activity in SKOV3 ovarian carcinoma cells and A549 lung carcinoma cells. Structure-Activity Relationship (SAR) analysis indicated that the
isomer and specific substitutions influenced the biological activity. Computational assays predicted favorable ADME properties, highlighting potential as anticancerous agents. Molecular docking studies demonstrated that compound
, with the
geometry of the double bond and fused polyaromatic rings such as phenanthrene, has robust interaction with tubulin, suggesting enhanced stability due to diverse amino acid interactions. Comparative spatial distributions with colchicine further indicated potential mechanistic similarities. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Rafael Peláez, University of Salamanca, Spain Reviewed by: Stanislav Yanev, Bulgarian Academy of Sciences (BAS), Bulgaria Afzal Basha Shaik, Jawaharlal Nehru Technological University, Kakinada, India |
ISSN: | 1663-9812 1663-9812 |
DOI: | 10.3389/fphar.2024.1344042 |