Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties

Emodin and scoparone, the active principles isolated from Polygonum multiflorum and Artemisia scoparia, respectively, both exhibit vasorelaxant and immunosuppressive effects. Emodin (10(-6)-3 x 10(-5) M) and scoparone (10(-6)-3 x 10(-5) M) dose dependently relaxed rat thoracic aortic rings precontra...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 198; no. 2-3; p. 211
Main Authors Huang, H C, Chu, S H, Chao, P D
Format Journal Article
LanguageEnglish
Published Netherlands 06.06.1991
Subjects
Animals
Coumarins - pharmacology
Emodin - pharmacology
Humans
Immunosuppressive Agents
Lymphocyte Activation - drug effects
Lymphocyte Culture Test, Mixed
Muscle Relaxation - drug effects
Muscle, Smooth, Vascular - drug effects
Phenylephrine - pharmacology
Rats
Rats, Inbred Strains
Thoracic Arteries - drug effects
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Summary:Emodin and scoparone, the active principles isolated from Polygonum multiflorum and Artemisia scoparia, respectively, both exhibit vasorelaxant and immunosuppressive effects. Emodin (10(-6)-3 x 10(-5) M) and scoparone (10(-6)-3 x 10(-5) M) dose dependently relaxed rat thoracic aortic rings precontracted with phenylephrine. Emodin (3 x 10(-7)-10(-4) M) and scoparone (10(-6)-3 x 10(-4) M) also dose dependently suppressed the responses of human mononuclear cells to phytohemagglutinin and mixed lymphocyte reaction. These compounds may be useful as new templates for the development of better immunosuppressive agents with vasorelaxant actions for use against transplantation rejection and autoimmune disease.
ISSN:0014-2999
DOI:10.1016/0014-2999(91)90624-Y