Immediate rebound followed by deterioration of regional left ventricular function with coronary reperfusion

• Published in: Journal of the American College of Cardiology Vol. 8; no. 2; pp. 333 - 341
• Main Authors: Buda, Andrew J., Zots, Rainer J., Pace, Diane P., Krause, Lisa C., Turla, Mila
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.1986; Elsevier Science
• Subjects: Animals; Autoradiography; Biological and medical sciences; Cardiology. Vascular system; Coronary Circulation; Coronary heart disease; Dogs; Echocardiography; Heart; Heart Ventricles - physiopathology; Hemodynamics; Medical sciences; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Perfusion; Time Factors; Heart; Fissipedia; Carnivora; Acute; Coronary artery; Cardiovascular disease; Coronary heart disease; Vertebrata; Experimental disease; Mammalia; Hemodynamics; Obliteration; Left ventricle performance; Dog
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/S0735-1097(86)80048-1

The immediate and early effects of coronary artery re-perfusion initiated 1 and 3 hours after coronary artery occlusion were evaluated by two-dimensional echocar-diographic measurements of overall and regional left ventricular function. A total of 29 anesthetized open chest dogs underwent one of the following: 1 hour occlusion followed by reperfusion (Group I, n = 9), 3 hour occlusion followed by reperfusion (Group II, n = 12) or 5 hour occlusion without reperfusion (Group III, n = 8). Serial two-dimensional echocardiography was performed at baseline; at 1, 3 and 5 hours of coronary occlusion; within 5 minutes of reperfusion; and at 2 hours of reperfusion. After occlusion, all groups manifested significant (p < 0.01) increases in left ventricular diastolic and systolic area and decreases in left ventricular area ejection fraction. With coronary reperfusion, there was no improvement in these global variables in Groups I and II. However, immediately after reperfusion, there was improvement in the regional extent of dysfunction (Group I, 138 ± 35 to 66 ± 62°, p < 0.05; Group II, 156 ± 51 to 85 ± 77°, p < 0.05) as well as improvement in the regional degree of dyskinesia (p < 0.05). These regional improvements were transient and resolved by 2 hours of coronary reperfusion. This immediate rebound of function was not associated with the duration of coronary occlusion, hemodynamic variables or ultimate infarct size. Thus, in the anesthetized open chest dog model, coronary artery reperfusion at 1 or 3 hours produces an immediate but transient improvement in regional systolic myocardial function.