Choline Metabolites, Hydroxybutyrate and HDL after Dietary Fiber Supplementation in Overweight/Obese Hypertensive Women: A Metabolomic Study

• Published in: Nutrients Vol. 13; no. 5; p. 1437
• Main Authors: Dos Santos Fechine, Carla Patricia Novaes, Monteiro, Mussara Gomes Cavalcanti Alves, Tavares, Josean Fechine, Souto, Augusto Lopes, Luna, Rafaella Cristhine Pordeus, da Silva, Cássia Surama Oliveira, da Silva, Jairo Alves, Dos Santos, Sócrates Golzio, de Carvalho Costa, Maria José, Persuhn, Darlene Camati
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.04.2021; MDPI
• Subjects: Amino acids; Anticoagulants; Blood & organ donations; Blood pressure; Body weight; Carbohydrates; Choline; Dietary fiber; Dietary supplements; Ethylenediaminetetraacetic acid; Fiber in human nutrition; Food; High density lipoprotein; Hypertension; Information management; Intervention; Lipids; Metabolism; Metabolites; Metabolomics; Multivariate analysis; NMR; Nuclear magnetic resonance; Obesity; Overweight; Prevention; Principal components analysis; Software; Womens health; Brazil; dietary fiber; metabolomics; hypertension; nuclear magnetic resonance; obesity
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu13051437

Metabolomics has been increasingly used to evaluate metabolic changes associated with morbidities. The objective of this study is to assess the metabolic profile before and after intervention with mixed dietary fiber in overweight and obese hypertensive women. This is an intervention study, and the sample consists of 14 women aged 28 to 58 years. An intervention with 12 g of mixed soluble and insoluble fiber is performed for a period of eight weeks. Serum metabolites are identified using a Bruker H NMR spectrometer at 400 MHz. Multivariate data analysis, including principal component analysis (PCA), is used to differentiate the two groups. After supplementation with dietary fiber, there is a significant increase in the peak intensity values of the metabolites HDL-C (0.0010*), choline (0.0012*) and hydroxybutyrate (0.0010*) as well as a decrease in systolic (0.0013*) and diastolic (0.0026*) blood pressure. The analysis of the metabolomic profile allows the identification of metabolites that have been associated in the literature with hypertension and excess weight (choline, hydroxybutyrate and amino acids) and with fiber intake (choline, hydroxybutyrate and amino acids) in addition to an increase in HDL-C. The increase in the detection of the described metabolites possibly occurs due to the presence of pathologies and the use of fiber in the intervention, which also contributes to elevated HDL-c and reduced blood pressure.