Satb1: Restraining PD1 and T Cell Exhaustion

Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity. Mechanisms that govern PD1 expression and exhaustio...

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Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 46; no. 1; pp. 3 - 5
Main Authors Nixon, Briana G., Li, Ming O.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 17.01.2017
Elsevier Limited
Subjects
Constraining
Cytokines
Exhaustion
Gene expression
Genome
Genomes
Genotype & phenotype
Humans
Immunity
Immunotherapy
Influence
Lymphocytes
Lymphocytes T
Matrix Attachment Region Binding Proteins - genetics
Proteins
Rodents
Studies
T cell receptors
T-Lymphocytes
Tumors
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Summary:Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity. Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2017.01.002