Increased numbers of sodium channels form along demyelinated axons

Sodium channels, which are largely localized to the nodes of Ranvier in myelinated axons, appear to form new distributions along demyelinated axons. In this study a sensitive radioimmunoassay (RIA) was used to examine the changes in the total number of sodium channels that occur in nerves experiment...

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Bibliographic Details
Published inBrain research Vol. 548; no. 1-2; p. 334
Main Authors England, J D, Gamboni, F, Levinson, S R
Format Journal Article
LanguageEnglish
Published Netherlands 10.05.1991
Subjects
Animals
Axons - drug effects
Axons - physiology
Carrier Proteins - metabolism
Doxorubicin - pharmacology
Electric Organ - physiology
Electrophorus
Myelin Sheath - drug effects
Myelin Sheath - physiology
Radioimmunoassay
Ranvier's Nodes - drug effects
Ranvier's Nodes - physiology
Sodium Channels - drug effects
Sodium Channels - physiology
Tetrodotoxin - metabolism
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Summary:Sodium channels, which are largely localized to the nodes of Ranvier in myelinated axons, appear to form new distributions along demyelinated axons. In this study a sensitive radioimmunoassay (RIA) was used to examine the changes in the total number of sodium channels that occur in nerves experimentally demyelinated in vivo with doxorubicin (adriamycin). The results clearly illustrate the development of an increased number of sodium channels during demyelination, suggesting that this process is associated with the formation of new sodium channels.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(91)91144-P