Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity
The success of the human body in fighting SARS-CoV2 infection relies on lymphocytes and their antigen receptors. Identifying and characterizing clinically relevant receptors is of utmost importance. We report here the application of a machine learning approach, utilizing B cell receptor repertoire s...
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Published in | Frontiers in immunology Vol. 14; p. 1031914 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
19.04.2023
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Subjects | |
Online Access | Get full text |
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Summary: | The success of the human body in fighting SARS-CoV2 infection relies on lymphocytes and their antigen receptors. Identifying and characterizing clinically relevant receptors is of utmost importance.
We report here the application of a machine learning approach, utilizing B cell receptor repertoire sequencing data from severely and mildly infected individuals with SARS-CoV2 compared with uninfected controls.
In contrast to previous studies, our approach successfully stratifies non-infected from infected individuals, as well as disease level of severity. The features that drive this classification are based on somatic hypermutation patterns, and point to alterations in the somatic hypermutation process in COVID-19 patients.
These features may be used to build and adapt therapeutic strategies to COVID-19, in particular to quantitatively assess potential diagnostic and therapeutic antibodies. These results constitute a proof of concept for future epidemiological challenges. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Valentyn Oksenych, University of Oslo, Norway; Youpeng Fan, Southwest University, China This article was submitted to Viral Immunology, a section of the journal Frontiers in Immunology Edited by: Pei-Hui Wang, Shandong University, China |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2023.1031914 |