High plasma levels of the pro-inflammatory cytokine IL-22 and the anti-inflammatory cytokines IL-10 and IL-1ra in acute pancreatitis

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 14; no. 6; pp. 465 - 469
• Main Authors: Vasseur, Philippe, Devaure, Iris, Sellier, Jacques, Delwail, Adriana, Chagneau-Derrode, Carine, Charier, Florian, Tougeron, David, Tasu, Jean-Pierre, Rabeony, Hanitriniaina, Lecron, Jean-Claude, Silvain, Christine
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.11.2014; Elsevier Limited
• Subjects: Acute Disease; Acute pancreatitis; Adult; Aged; Aged, 80 and over; Bacterial infections; Cytokines; Endocrinology & Metabolism; Female; Gastroenterology and Hepatology; Humans; IL-10; IL-1ra; IL-22; Infections - complications; Interleukin 1 Receptor Antagonist Protein - blood; Interleukin-10 - blood; Interleukin-22; Interleukins - blood; Male; Middle Aged; Mortality; Necrosis infection; Pancreas; Pancreatitis, Acute Necrotizing - blood; Pancreatitis, Acute Necrotizing - complications; Plasma; Pleural Effusion, Malignant - complications; Prognosis; Prospective Studies; Respiratory distress syndrome; Tomography, X-Ray Computed; Young Adult; Acute pancreatitis; Necrosis infection; IL-1ra; SAP; IL; Cytokines; severe acute pancreatitis; interleukine; IL-22; IL-10; acute pancreatits; AP

Abstract Background/objectives Pancreatic acinar cells are major targets of IL-22. Our aim is to study early plasma levels of IL-22, of pro- and anti-inflammatory cytokines in acute pancreatitis, and their association with severity or necrosis infection. Methods Consecutive patients admitted to the...