Trends in mitochondrial unfolded protein response research from 2004 to 2022: A bibliometric analysis
The mitochondrial unfolded protein response (UPR ) is a stress response pathway that regulates the expression of mitochondrial chaperones, proteases, and other proteins involved in protein folding and degradation, thereby ensuring proper mitochondrial function. In addition to this critical function,...
Saved in:
Published in | Frontiers in cell and developmental biology Vol. 11; p. 1146963 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
24.03.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The mitochondrial unfolded protein response (UPR
) is a stress response pathway that regulates the expression of mitochondrial chaperones, proteases, and other proteins involved in protein folding and degradation, thereby ensuring proper mitochondrial function. In addition to this critical function, the UPR
also plays a role in other cellular processes such as mitochondrial biogenesis, energy metabolism, and cellular signaling. Moreover, the UPR
is strongly associated with various diseases. From 2004 to 2022, there has been a lot of interest in UPR
. The present study aims to utilized bibliometric tools to assess the genesis, current areas of focus, and research trends pertaining to UPR
, thereby highlighting avenues for future research. There were 442 papers discovered to be related to UPR
, with the overall number of publications rising yearly.
was the most prominent journal in this field. 2421 authors from 1,402 institutions in 184 nations published studies on UPR
. The United States was the most productive country (197 documents). The top three authors were Johan Auwerx, Cole M Haynes, and Dongryeol Ryu. The early focus of UPR
is "protein." And then the UPR
research shifted from
back to mammals, and its close link to aging and various diseases. The top emerging research hotspots are neurodegenerative diseases and metabolic diseases. These findings provide the trends and frontiers in the field of UPR
, and valuable information for clinicians and scientists to identify new perspectives with potential collaborators and cooperative countries. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Vandre Casagrande Figueiredo, Oakland University, United States Reviewed by: Leonardo Matta Pereira, Federal University of Rio de Janeiro, Brazil Eirini Lionaki, Foundation for Research and Technology Hellas (FORTH), Greece These authors have contributed equally to this work and share first authorship This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology |
ISSN: | 2296-634X 2296-634X |
DOI: | 10.3389/fcell.2023.1146963 |