Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states...

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Published inFrontiers in pharmacology Vol. 14; p. 1098976
Main Authors Ma, Wei-Xiang, Yuan, Ping-Chuan, Zhang, Hui, Kong, Ling-Xi, Lazarus, Michael, Qu, Wei-Min, Wang, Yi-Qun, Huang, Zhi-Li
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.03.2023
Subjects
adenosine
hibernation
P1 receptors
Pharmacology
sleep
torpor
adenosine
sleep
P1 receptors
hibernation
torpor
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Summary:Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states, suggesting that adenosine and its receptors, also known as P1 receptors, may mediate the initiation and maintenance of these states. This review, therefore, summarizes the current research on the roles and possible neurobiological mechanisms of adenosine and P1 receptors in sleep, torpor, and hibernation. Understanding these aspects will give us better prospects in sleep disorders, therapeutic hypothermia, and aerospace medicine.
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Edited by: Yong Tang, Chengdu University of Traditional Chinese Medicine, China
Reviewed by: Aleksandra Korac
These authors have contributed equally to this work
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
Shangdong Liang, Nanchang University, China
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2023.1098976