E2 enzymes： more than just middle men

Ubiquitin-conjugating enzymes （E2s） are the central players in the trio of enzymes responsible for the attachment of ubiquitin （Ub） to cellular proteins. Humans have -40 E2s that are involved in the transfer of Ub or Ub-like （Ubl） proteins （e.g., SUMO and NEDDS）. Although the majority of E2s are onl...

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Bibliographic Details
Published inCell research Vol. 26; no. 4; pp. 423 - 440
Main Authors Stewart, Mikaela D, Ritterhoff, Tobias, Klevit, Rachel E, Brzovic, Peter S
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.04.2016
Nature Publishing Group
Subjects
631/45/173
631/45/535
631/45/607/1166
631/45/612/645
Animals
Biomedical and Life Sciences
Cell Biology
Gene Expression Regulation
Humans
Life Sciences
Review
Ubiquitin-Conjugating Enzymes - chemistry
Ubiquitin-Conjugating Enzymes - metabolism
Ubiquitin-Protein Ligases - metabolism
中间人
家族
泛素连接酶
细胞
结合酶
蛋白质
ubiquitin-conjugating enzymes
E2
RING
HECT
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Summary:Ubiquitin-conjugating enzymes （E2s） are the central players in the trio of enzymes responsible for the attachment of ubiquitin （Ub） to cellular proteins. Humans have -40 E2s that are involved in the transfer of Ub or Ub-like （Ubl） proteins （e.g., SUMO and NEDDS）. Although the majority of E2s are only twice the size of Ub, this remarkable family of enzymes performs a variety of functional roles. In this review, we summarize common functional and structural features that define unifying themes among E2s and highlight emerging concepts in the mechanism and regulation of E2s.
Bibliography:E2; ubiquitin-conjugating enzymes; HECT; RING
Ubiquitin-conjugating enzymes （E2s） are the central players in the trio of enzymes responsible for the attachment of ubiquitin （Ub） to cellular proteins. Humans have -40 E2s that are involved in the transfer of Ub or Ub-like （Ubl） proteins （e.g., SUMO and NEDDS）. Although the majority of E2s are only twice the size of Ub, this remarkable family of enzymes performs a variety of functional roles. In this review, we summarize common functional and structural features that define unifying themes among E2s and highlight emerging concepts in the mechanism and regulation of E2s.
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These two authors contributed equally to this work.
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2016.35