Pseudogene BMI1P1 expression as a novel predictor for acute myeloid leukemia development and prognosis

• Published in: Oncotarget Vol. 7; no. 30; pp. 47376 - 47386
• Main Authors: Zhou, Ling-Yu, Zhai, Ling-Ling, Yin, Jia-Yu, Vanessa, Minse Evola-Deniz, Zhou, Jiao, Zhang, Jing, Tang, Xi, Lin, Jiang, Qian, Jun, Deng, Zhao-Qun
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 26.07.2016
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Leukemia, Myeloid, Acute - etiology; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Male; Middle Aged; Polycomb Repressive Complex 1 - genetics; Prognosis; Pseudogenes; Research Paper; Young Adult; BMI1P1; pseudogene; acute myeloid leukemia; tumor marker

The BMI1P1 levels of 144 de novo AML patients and 36 healthy donors were detected by real-time quantitative PCR (RQ-PCR). BMI1P1 was significantly down-regulated in AML compared with control (P < 0.001). A receiver operating characteristic (ROC) curve revealed that BMI1P1 expression could differe...