Current perspectives of mitochondria-targeted antioxidants in cancer prevention and treatment

Oxidative stress nearly always accompanies all stages of cancer development. At the early stages, antioxidants may help to reduce reactive oxygen species (ROS) production and exhibit anticarcinogenic effects. In the later stages, ROS involvement becomes more complex. On the one hand, ROS are necessa...

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Published inFrontiers in cell and developmental biology Vol. 11; p. 1048177
Main Authors Zinovkin, Roman A, Lyamzaev, Konstantin G, Chernyak, Boris V
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.03.2023
Subjects
cancer development
cancer therapy
Cell and Developmental Biology
mitochondria-targeted antioxidants
mitochondrial ROS
oxidative stress
cancer therapy
mitochondria-targeted antioxidants
mitochondrial ROS
cancer development
oxidative stress
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Summary:Oxidative stress nearly always accompanies all stages of cancer development. At the early stages, antioxidants may help to reduce reactive oxygen species (ROS) production and exhibit anticarcinogenic effects. In the later stages, ROS involvement becomes more complex. On the one hand, ROS are necessary for cancer progression and epithelial-mesenchymal transition. On the other hand, antioxidants may promote cancer cell survival and may increase metastatic frequency. The role of mitochondrial ROS in cancer development remains largely unknown. This paper reviews experimental data on the effects of both endogenous and exogenous antioxidants on cancerogenesis focusing on the development and application of mitochondria-targeted antioxidants. We also discuss the prospects for antioxidant cancer therapy, focusing on the use of mitochondria-targeted antioxidants.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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Edited by: Saverio Marchi, Marche Polytechnic University, Italy
Alessandro Rimessi, University of Ferrara, Italy
Reviewed by: Daniela Valenti, National Research Council (CNR), Italy
This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2023.1048177