Glucagon-like peptide-1 receptor-agonists treatment for cardio-metabolic parameters in schizophrenia patients: a systematic review and meta-analysis

• Published in: Frontiers in psychiatry Vol. 14; p. 1153648
• Main Authors: Khaity, Abdulrhman, Mostafa Al-Dardery, Nada, Albakri, Khaled, Abdelwahab, Omar A, Hefnawy, Mahmoud Tarek, Yousef, Yaman A S, Taha, Ruaa E, Swed, Sarya, Hafez, Wael, Hurlemann, Rene, Elsayed, Mohamed E G
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.05.2023
• Subjects: GLP-1 receptor agonists; meta-analysis; Psychiatry; schizophrenia; systematic review; treatment; meta-analysis; treatment; schizophrenia; systematic review; GLP-1 receptor agonists
• ISSN: 1664-0640; 1664-0640
• DOI: 10.3389/fpsyt.2023.1153648

We performed this meta-analysis to evaluate the efficacy and safety of glucagon-like peptide-1 receptor-agonists (GLP-1RA) treatment on cardio-metabolic parameters among antipsychotic-treated patients with schizophrenia. We searched the Web of Science, Cochrane Central Register of Controlled Trials, PubMed, PsycINFO, and Scopus for relevant Randomized Clinical trials (RCTs) from inception until 1 August 2022. Documents were screened for qualified articles, and all concerned outcomes were pooled as risk ratios (RR) or mean difference (MD) in the meta-analysis models using Review Manager (RevMan version 5.4). Pooling data from 7 RCTs (398 patients) showed that GLP-1 RA was superior to placebo with regard to body weight [MD = - 4.68, 95% CI (-4.90,-4.46), < 0.00001], waist circumference [MD = - 3.66, 95% CI (-3.89,-3.44), < 0.00001], body mass index (BMI) [MD = - 1.09, 95% CI (-1.25,-0.93), < 0.00001], systolic blood pressure (SBP) [MD = - 3.07, 95% CI (-3.61,-2.53), < 0.00001], and diastolic blood pressure (DBP) [MD = - 2.02, 95% CI (-2.42,-1.62), < 0.00001]. The total effect did not favor either of the two groups with respect to insulin and respiratory adverse events {[MD = - 0.06, 95% CI (-0.36, 0.24), = 0.70], [RR = 0.66, 95% CI (0.31, 1.40), = 0.28]; respectively}. Our analysis revealed that GLP-1 RA treatment is safe and effective on cardio-metabolic parameters over control in antipsychotic-treated patients with schizophrenia. Nevertheless, the present evidence is not sufficient to confirm the safety and efficacy of GLP-1RA treatment on insulin and respiratory adverse events. Therefore, further studies are recommended. http://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022333040.