Possible involvement of nitric oxide in long-term potentiation

Long-term potentiation (LTP) in the hippocampus is known to involve NMDA (N-methyl-D-aspartate) receptors. Since activation of NMDA receptors in the cerebellum results in the formation of nitric oxide (NO), we studied the possible involvement of this messenger in hippocampal synaptic plasticity. We...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 199; no. 3; p. 379
Main Authors Böhme, G A, Bon, C, Stutzmann, J M, Doble, A, Blanchard, J C
Format Journal Article
LanguageEnglish
Published Netherlands 09.07.1991
Subjects
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
Hippocampus - drug effects
Hippocampus - physiology
Male
Neuronal Plasticity - physiology
Nitric Oxide - metabolism
Nitroarginine
Nitroprusside - pharmacology
Rats
Rats, Inbred Strains
Synapses - drug effects
Synapses - physiology
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Summary:Long-term potentiation (LTP) in the hippocampus is known to involve NMDA (N-methyl-D-aspartate) receptors. Since activation of NMDA receptors in the cerebellum results in the formation of nitric oxide (NO), we studied the possible involvement of this messenger in hippocampal synaptic plasticity. We report here that the NO-synthase inhibitor, L-N omega-nitro-arginine, blocks LTP and that sodium nitroprusside, which releases NO, produces a long-lasting enhancement in synaptic efficacy which is not additive with tetanus-induced LTP.
ISSN:0014-2999
DOI:10.1016/0014-2999(91)90505-K