Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging

The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammatio...

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Published inFrontiers in endocrinology (Lausanne) Vol. 14; p. 1324429
Main Authors Orisaka, Makoto, Mizutani, Tetsuya, Miyazaki, Yumiko, Shirafuji, Aya, Tamamura, Chiyo, Fujita, Masayuki, Tsuyoshi, Hideaki, Yoshida, Yoshio
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.12.2023
Subjects
Aging
Endocrinology
Endometriosis
Female
Fibrosis
follicular microenvironment
Humans
inflammation
Inflammation - complications
ovarian dysfunction
polycystic ovarian syndrome
Polycystic Ovary Syndrome - complications
Tumor Microenvironment
endometriosis
aging
follicular microenvironment
inflammation
ovarian dysfunction
polycystic ovarian syndrome
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Abstract The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction.
AbstractList The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction.
The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction.The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction.
Author Yoshida, Yoshio
Shirafuji, Aya
Tamamura, Chiyo
Miyazaki, Yumiko
Orisaka, Makoto
Mizutani, Tetsuya
Tsuyoshi, Hideaki
Fujita, Masayuki
AuthorAffiliation 2 Department of Nursing, Faculty of Nursing and Welfare Sciences, Fukui Prefectural University , Fukui , Japan
3 Department of Obstetrics and Gynecology, Ishikawa Prefectural Central Hospital , Ishikawa , Japan
1 Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui , Fukui , Japan
AuthorAffiliation_xml – name: 3 Department of Obstetrics and Gynecology, Ishikawa Prefectural Central Hospital , Ishikawa , Japan
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Cites_doi 10.1210/en.2008-1536
10.1016/j.tem.2019.04.006
10.1177/1933719108330087
10.1186/s13048-017-0341-4
10.1093/humupd/dmt053
10.1210/endo.130.3.1537322
10.1007/s43032-022-01083-x
10.1111/imr.12295
10.1172/jci.insight.125185
10.1210/endo-126-5-2711
10.1016/j.rbmo.2019.12.005
10.1038/srep18858
10.1095/biolreprod61.4.993
10.1007/s43032-022-01135-2
10.1093/biolre/ioab050
10.1038/s41419-022-05037-8
10.1387/ijdb.120133cc
10.1093/biolre/iox140
10.1016/j.cub.2014.03.034
10.1093/biolre/ioab241
10.1186/s40738-020-00094-z
10.2174/1874609813666200929112624
10.1038/srep10779
10.1016/S0015-0282(03)00344-3
10.3390/ijms22094642
10.1093/humupd/dmab038
10.1038/nrrheum.2017.172
10.1186/s12958-022-01033-x
10.1016/j.rbmo.2014.03.010
10.1111/acel.13259
10.1126/sciadv.abn4564
10.1016/j.fertnstert.2013.12.049
10.1210/jc.2013-3942
10.1093/humupd/dmab014
10.1038/s41591-019-0675-0
10.1016/j.rbmo.2014.04.019
10.1002/jcp.27603
10.4103/0366-6999.198931
10.1371/journal.pone.0049217
10.1017/S0967199420000222
10.1093/humrep/deq306
10.1016/j.theriogenology.2010.10.029
10.1530/REP-19-0330
10.1016/s0029-7844(03)00233-3
10.1530/REP-18-0583
10.1007/s10815-016-0865-3
10.1093/molehr/gaw038
10.1097/00001648-199403000-00016
10.1016/0303-7207(89)90118-4
10.1111/cen.12951
10.1073/pnas.1323955111
10.1097/OGX.0b013e31815e85fc
10.1007/s43032-019-00137-x
10.1530/REP-21-0022
10.1016/j.ejogrb.2011.07.012
10.1677/joe.0.1700121
10.1210/edrv-15-6-707
10.1073/pnas.1312830110
10.1071/RD22204
10.1210/jc.2006-1665
10.1095/biolreprod50.1.38
10.1016/j.fertnstert.2013.04.022
10.1016/0002-9378(93)90093-X
10.1056/NEJMoa1110238
10.1097/00062752-200105000-00001
10.3389/fendo.2022.1020827
10.1016/j.fertnstert.2003.10.004
10.1007/s43032-020-00164-z
10.1111/aji.13265
10.1186/1757-2215-2-9
10.1080/15384101.2016.1208873
10.1038/ni.3790
10.1089/ars.2012.5149
10.1016/j.mce.2010.08.002
10.1007/s00441-016-2445-3
10.3389/fcell.2022.1038107
10.1056/NEJMra041536
10.1080/15384101.2015.1026517
10.1038/s41598-017-11252-7
10.1023/A:1020363312252
10.1016/j.fertnstert.2009.08.068
10.1016/j.fertnstert.2014.03.053
10.1038/s41586-022-05388-4
10.1038/nchembio.2239
10.1385/ENDO:8:2:109
10.1210/er.2014-1020
10.1097/AOG.0000000000000592
10.1210/endo.137.11.8895358
10.1002/rmb2.12371
10.1093/humupd/dmac031
10.1084/jem.20190103
10.1210/en.2013-1821
10.1093/humupd/dmm048
10.1016/j.cell.2012.03.042
10.1210/endo-128-1-379
10.1016/S0006-291X(02)00431-X
10.1038/nchembio.2238
10.3109/09513590.2011.579652
10.1017/S0954422418000136
10.1016/j.fertnstert.2009.01.131
10.1210/er.2018-00242
10.1080/09513590.2017.1371691
10.1016/j.fertnstert.2011.06.064
10.1093/gerona/glu057
10.3390/jcm12041454
10.3389/fendo.2023.1174817
10.1093/humrep/10.suppl_2.91
10.3389/fendo.2022.921032
10.1017/S0954422416000287
10.1016/j.cell.2015.02.010
10.1210/endo.136.7.7540548
10.1093/humrep/det341
10.1016/j.fertnstert.2014.11.015
10.1007/s00281-019-00737-4
10.1093/oxfordjournals.humrep.a138578
10.1093/humrep/det466
10.1016/j.tem.2016.11.008
10.1074/mcp.RA118.000620
10.1016/S0165-0378(97)00077-6
10.1016/S0378-5122(98)00068-1
10.1038/nm.2807
10.1093/humupd/dmq032
10.1016/j.arr.2008.07.002
10.1002/jcp.28819
10.1530/REP-16-0129
10.1038/s41598-020-79488-4
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Copyright Copyright © 2023 Orisaka, Mizutani, Miyazaki, Shirafuji, Tamamura, Fujita, Tsuyoshi and Yoshida.
Copyright © 2023 Orisaka, Mizutani, Miyazaki, Shirafuji, Tamamura, Fujita, Tsuyoshi and Yoshida 2023 Orisaka, Mizutani, Miyazaki, Shirafuji, Tamamura, Fujita, Tsuyoshi and Yoshida
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Keywords endometriosis
aging
follicular microenvironment
inflammation
ovarian dysfunction
polycystic ovarian syndrome
Language English
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Fardin Amidi, Tehran University of Medical Sciences, Iran
Reviewed by: Miyuki Harada, The University of Tokyo, Japan
Edited by: Takashi Minegishi, Gunma University, Japan
Takashi Yazawa, Asahikawa Medical University, Japan
Akira Iwase, Gunma University, Japan
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References Secomandi (B126) 2022; 28
Alpizar (B43) 1994; 50
Matsuzaki (B100) 2010; 93
Bruunsgaard (B7) 2001; 8
Palini (B50) 2014; 29
Chung (B8) 2009; 8
Palomba (B71) 2017; 28
(B53) 2004; 81
Park (B111) 2021; 162
Popovic (B38) 2019; 41
Rodichkina (B112) 2021; 14
Artimani (B60) 2018; 34
Silva (B26) 2020; 28
Chun (B36) 1995; 136
Franceschi (B114) 2014
Orisaka (B18) 2021; 20
Orisaka (B122) 2009; 2
Spicer (B32) 1998; 8
Ng (B94) 2020; 27
Babayev (B47) 2022; 106
Amargant (B123) 2020; 19
Repaci (B57) 2011; 335
Luzzo (B68) 2012; 7
Imai (B44) 2014; 155
Amato (B58) 2003; 101
Corachán (B84) 2021; 27
Cui (B33) 2011; 75
Sanchez (B93) 2014; 29
Cortón (B75) 2007; 92
Hamdan (B87) 2015; 125
Straub (B3) 2017; 13
Ni (B98) 2022; 13
Yang (B27) 2020; 84
Roby (B31) 1990; 126
Gorospe (B42) 1992; 130
Coccia (B88) 2014; 29
Wang (B67) 2018; 17
Pellicer (B105) 1995
Bonavina (B89) 2022; 13
Zhang (B117) 2020; 159
Hsueh (B19) 1994; 15
Fu (B81) 2023; 30
Molinari (B124) 2016; 22
Bulun (B85) 2019; 40
Sanchez (B17) 2014; 20
Nikbakht (B56) 2021; 7
Basini (B35) 1998; 37
Kotas (B2) 2015; 160
Ma (B34) 2010; 93
Grodstein (B63) 1994; 5
Ehrmann (B73) 2005; 352
Tatone (B119) 2008; 14
Yland (B92) 2020; 40
Sanchez (B91) 2017; 10
Shen (B120) 2019; 234
Xiong (B61) 2011; 159
Furman (B4) 2019; 25
Dumesic (B70) 2008; 63
Dumesic (B48) 2015; 103
Xu (B76) 1991; 128
Herrera (B13) 2019; 4
Mittal (B10) 2014; 20
Hennet (B21) 2012; 56
Singh (B54) 2023; 12
Yuan (B118) 2016; 15
Arroyo (B20) 2020; 27
Kasson (B39) 1989; 62
Zhang (B69) 2015; 14
Machelon (B40) 1994; 40
Niu (B77) 2014; 99
Hou (B66) 2016; 6
Frangogiannis (B15) 2020; 217
Teede (B52) 2019; 30
Maneschi (B86) 1993; 169
Dixon (B95) 2012; 149
Uri-Belapolsky (B37) 2014; 111
Gallinelli (B59) 2003; 79
O’Connor (B110) 1998; 30
Goud (B107) 2014; 102
Kaipia (B28) 1996; 137
Tamura (B41) 2001; 170
Kawamura (B23) 2013; 110
Shi (B103) 2017; 97
Sasson (B29) 2002; 294
Netea (B1) 2017; 18
Leroy (B51) 2022; 35
Esencan (B25) 2022; 20
Weiss (B5) 2009; 16
Schieber (B11) 2014; 24
Spaczynski (B30) 1999; 61
Barrea (B55) 2018; 31
Younis (B109) 2022; 13
Jeanes (B72) 2017; 30
Xu (B108) 2015; 5
Luke (B113) 2012; 366
Wynn (B12) 2012; 18
Yaribeygi (B74) 2019; 234
Velez (B6) 2021; 104
Simón (B106) 1994; 9
Takahashi (B83) 2017; 7
Qiao (B62) 2011; 17
Bedaiwy (B49) 2012; 28
Goldberg (B115) 2015; 265
Lliberos (B46) 2021; 11
Zhou (B78) 2017; 130
Tal (B79) 2013; 100
Wu (B90) 2017; 34
Zhang (B82) 2013; 28
Orisaka (B121) 2009; 150
Garcia Garcia (B99) 2023; 30
Snider (B65) 2019; 158
Kagan (B97) 2017; 13
Briley (B45) 2016; 152
Xia (B104) 2023; 14
Liu (B80) 2015; 83
Fiorentino (B22) 2023; 29
Luke (B64) 2011; 26
Richter (B14) 2016; 365
Juan (B9) 2021; 22
Pellicer (B116) 1999; 16
Hsueh (B24) 2015; 36
Biswas (B16) 2022; 10
Kitajima (B102) 2014; 101
Umehara (B125) 2022; 8
Doll (B96) 2017; 13
Kitajima (B101) 2011; 96
Wang (B127) 2022; 611
References_xml – volume: 150
  year: 2009
  ident: B121
  article-title: Growth differentiation factor 9 promotes rat preantral follicle growth by up-regulating follicular androgen biosynthesis
  publication-title: Endocrinology
  doi: 10.1210/en.2008-1536
– volume: 30
  year: 2019
  ident: B52
  article-title: Anti-müllerian hormone in PCOS: A review informing international guidelines
  publication-title: Trends Endocrinol metabolism: TEM
  doi: 10.1016/j.tem.2019.04.006
– volume: 16
  year: 2009
  ident: B5
  article-title: Inflammation in reproductive disorders
  publication-title: Reprod Sci (Thousand Oaks Calif)
  doi: 10.1177/1933719108330087
– volume: 10
  start-page: 43
  year: 2017
  ident: B91
  article-title: Is the oocyte quality affected by endometriosis? A review of the literature
  publication-title: J Ovarian Res
  doi: 10.1186/s13048-017-0341-4
– volume: 20
  year: 2014
  ident: B17
  article-title: The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmt053
– volume: 130
  year: 1992
  ident: B42
  article-title: Interleukin-6: effects on and production by rat granulosa cells in vitro
  publication-title: Endocrinology
  doi: 10.1210/endo.130.3.1537322
– volume: 30
  year: 2023
  ident: B99
  article-title: Endometriosis: cellular and molecular mechanisms leading to fibrosis
  publication-title: Reprod Sci (Thousand Oaks Calif)
  doi: 10.1007/s43032-022-01083-x
– volume: 265
  start-page: 63
  year: 2015
  ident: B115
  article-title: Drivers of age-related inflammation and strategies for healthspan extension
  publication-title: Immunol Rev
  doi: 10.1111/imr.12295
– volume: 4
  year: 2019
  ident: B13
  article-title: Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.125185
– volume: 126
  year: 1990
  ident: B31
  article-title: Effects of tumor necrosis factor-alpha in vitro on steroidogenesis of healthy and atretic follicles of the rat: theca as a target
  publication-title: Endocrinology
  doi: 10.1210/endo-126-5-2711
– volume: 40
  start-page: 399
  year: 2020
  ident: B92
  article-title: Endometrioma, the follicular fluid inflammatory network and its association with oocyte and embryo characteristics
  publication-title: Reprod biomedicine Online
  doi: 10.1016/j.rbmo.2019.12.005
– volume: 6
  start-page: 18858
  year: 2016
  ident: B66
  article-title: Both diet and gene mutation induced obesity affect oocyte quality in mice
  publication-title: Sci Rep
  doi: 10.1038/srep18858
– volume: 61
  year: 1999
  ident: B30
  article-title: Tumor necrosis factor-alpha stimulates proliferation of rat ovarian theca-interstitial cells
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod61.4.993
– volume: 30
  year: 2023
  ident: B81
  article-title: Expression and clinical significance of HIF-1α in follicular fluid and granulosa cells in infertile PCOS patients
  publication-title: Reprod Sci (Thousand Oaks Calif)
  doi: 10.1007/s43032-022-01135-2
– volume: 104
  year: 2021
  ident: B6
  article-title: Inflammation and reproductive function in women with polycystic ovary syndrome†
  publication-title: Biol Reprod
  doi: 10.1093/biolre/ioab050
– volume: 13
  start-page: 579
  year: 2022
  ident: B98
  article-title: Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-022-05037-8
– volume: 56
  year: 2012
  ident: B21
  article-title: The antral follicle: a microenvironment for oocyte differentiation
  publication-title: Int J Dev Biol
  doi: 10.1387/ijdb.120133cc
– volume: 97
  year: 2017
  ident: B103
  article-title: Transforming growth factor beta1 from endometriomas promotes fibrosis in surrounding ovarian tissues via Smad2/3 signaling
  publication-title: Biol Reprod
  doi: 10.1093/biolre/iox140
– volume: 24
  year: 2014
  ident: B11
  article-title: ROS function in redox signaling and oxidative stress
  publication-title: Curr biology: CB
  doi: 10.1016/j.cub.2014.03.034
– volume: 106
  year: 2022
  ident: B47
  article-title: Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality
  publication-title: Biol Reprod
  doi: 10.1093/biolre/ioab241
– volume: 7
  start-page: 2
  year: 2021
  ident: B56
  article-title: Evaluation of oocyte quality in Polycystic ovary syndrome patients undergoing ART cycles
  publication-title: Fertility Res Pract
  doi: 10.1186/s40738-020-00094-z
– volume: 14
  year: 2021
  ident: B112
  article-title: Inflammaging of female reproductive system: A molecular landscape
  publication-title: Curr Aging Sci
  doi: 10.2174/1874609813666200929112624
– volume: 5
  start-page: 10779
  year: 2015
  ident: B108
  article-title: Oocyte quality is decreased in women with minimal or mild endometriosis
  publication-title: Sci Rep
  doi: 10.1038/srep10779
– volume: 79
  year: 2003
  ident: B59
  article-title: Correlations between concentrations of interleukin-12 and interleukin-13 and lymphocyte subsets in the follicular fluid of women with and without polycystic ovary syndrome
  publication-title: Fertility sterility
  doi: 10.1016/S0015-0282(03)00344-3
– volume: 22
  start-page: 4642
  year: 2021
  ident: B9
  article-title: The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms22094642
– volume: 28
  year: 2022
  ident: B126
  article-title: The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmab038
– volume: 13
  year: 2017
  ident: B3
  article-title: The brain and immune system prompt energy shortage in chronic inflammation and ageing
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2017.172
– volume: 20
  start-page: 156
  year: 2022
  ident: B25
  article-title: Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review
  publication-title: Reprod Biol endocrinology: RB&E
  doi: 10.1186/s12958-022-01033-x
– volume: 29
  start-page: 65
  year: 2014
  ident: B50
  article-title: Influence of ovarian stimulation for IVF/ICSI on the antioxidant defence system and relationship to outcome
  publication-title: Reprod biomedicine Online
  doi: 10.1016/j.rbmo.2014.03.010
– volume: 19
  year: 2020
  ident: B123
  article-title: Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices
  publication-title: Aging Cell
  doi: 10.1111/acel.13259
– volume: 8
  year: 2022
  ident: B125
  article-title: Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary
  publication-title: Sci Adv
  doi: 10.1126/sciadv.abn4564
– volume: 101
  year: 2014
  ident: B102
  article-title: Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas
  publication-title: Fertility sterility
  doi: 10.1016/j.fertnstert.2013.12.049
– volume: 99
  year: 2014
  ident: B77
  article-title: Associations between insulin resistance, free fatty acids, and oocyte quality in polycystic ovary syndrome during in vitro fertilization
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2013-3942
– volume: 27
  year: 2021
  ident: B84
  article-title: Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmab014
– volume: 25
  year: 2019
  ident: B4
  article-title: Chronic inflammation in the etiology of disease across the life span
  publication-title: Nat Med
  doi: 10.1038/s41591-019-0675-0
– volume: 29
  year: 2014
  ident: B88
  article-title: Is there a critical endometrioma size associated with reduced ovarian responsiveness in assisted reproduction techniques
  publication-title: Reprod biomedicine Online
  doi: 10.1016/j.rbmo.2014.04.019
– volume: 234
  year: 2019
  ident: B74
  article-title: Insulin resistance: Review of the underlying molecular mechanisms
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27603
– volume: 130
  year: 2017
  ident: B78
  article-title: Ovarian fibrosis: A phenomenon of concern
  publication-title: Chin Med J
  doi: 10.4103/0366-6999.198931
– volume: 7
  year: 2012
  ident: B68
  article-title: High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects
  publication-title: PloS One
  doi: 10.1371/journal.pone.0049217
– volume: 28
  year: 2020
  ident: B26
  article-title: Interleukin-1β and TNF-α systems in ovarian follicles and their roles during follicular development, oocyte maturation and ovulation
  publication-title: Zygote (Cambridge England)
  doi: 10.1017/S0967199420000222
– volume: 26
  year: 2011
  ident: B64
  article-title: Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates
  publication-title: Hum Reprod (Oxford England)
  doi: 10.1093/humrep/deq306
– volume: 75
  year: 2011
  ident: B33
  article-title: Tumor necrosis factor α knockout increases fertility of mice
  publication-title: Theriogenology
  doi: 10.1016/j.theriogenology.2010.10.029
– volume: 159
  year: 2020
  ident: B117
  article-title: Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary
  publication-title: Reprod (Cambridge England)
  doi: 10.1530/REP-19-0330
– volume: 101
  year: 2003
  ident: B58
  article-title: Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles
  publication-title: Obstetrics gynecology
  doi: 10.1016/s0029-7844(03)00233-3
– volume: 158
  start-page: R79
  year: 2019
  ident: B65
  article-title: Obesity induces ovarian inflammation and reduces oocyte quality
  publication-title: Reprod (Cambridge England)
  doi: 10.1530/REP-18-0583
– volume: 34
  year: 2017
  ident: B90
  article-title: Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis
  publication-title: J assisted Reprod Genet
  doi: 10.1007/s10815-016-0865-3
– volume: 22
  year: 2016
  ident: B124
  article-title: Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence
  publication-title: Mol Hum Reprod
  doi: 10.1093/molehr/gaw038
– volume: 5
  year: 1994
  ident: B63
  article-title: Body mass index and ovulatory infertility
  publication-title: Epidemiol (Cambridge Mass)
  doi: 10.1097/00001648-199403000-00016
– volume: 62
  year: 1989
  ident: B39
  article-title: Effects of interleukins 1, 2 and 3 on follicle-stimulating hormone-induced differentiation of rat granulosa cells
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/0303-7207(89)90118-4
– volume: 83
  year: 2015
  ident: B80
  article-title: Serum levels of TSP-1, NF-κB and TGF-β1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation
  publication-title: Clin Endocrinol
  doi: 10.1111/cen.12951
– volume: 111
  year: 2014
  ident: B37
  article-title: Interleukin-1 deficiency prolongs ovarian lifespan in mice
  publication-title: Proc Natl Acad Sci United States America
  doi: 10.1073/pnas.1323955111
– volume: 63
  start-page: 39
  year: 2008
  ident: B70
  article-title: Polycystic ovary syndrome and oocyte developmental competence
  publication-title: Obstetrical gynecological survey
  doi: 10.1097/OGX.0b013e31815e85fc
– volume: 27
  year: 2020
  ident: B20
  article-title: Luteinizing hormone action in human oocyte maturation and quality: signaling pathways, regulation, and clinical impact
  publication-title: Reprod Sci (Thousand Oaks Calif)
  doi: 10.1007/s43032-019-00137-x
– volume: 162
  start-page: R19
  year: 2021
  ident: B111
  article-title: Mechanisms of ovarian aging
  publication-title: Reprod (Cambridge England)
  doi: 10.1530/REP-21-0022
– volume: 159
  year: 2011
  ident: B61
  article-title: Low-grade chronic inflammation in the peripheral blood and ovaries of women with polycystic ovarian syndrome
  publication-title: Eur J obstetrics gynecology Reprod Biol
  doi: 10.1016/j.ejogrb.2011.07.012
– volume: 170
  year: 2001
  ident: B41
  article-title: Interleukin-6 inhibits the expression of luteinizing hormone receptor mRNA during the maturation of cultured rat granulosa cells
  publication-title: J Endocrinol
  doi: 10.1677/joe.0.1700121
– volume: 15
  year: 1994
  ident: B19
  article-title: Ovarian follicle atresia: a hormonally controlled apoptotic process
  publication-title: Endocrine Rev
  doi: 10.1210/edrv-15-6-707
– volume: 110
  year: 2013
  ident: B23
  article-title: Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment
  publication-title: Proc Natl Acad Sci United States America
  doi: 10.1073/pnas.1312830110
– volume: 35
  start-page: 1
  year: 2022
  ident: B51
  article-title: Maternal metabolic health and fertility: we should not only care about but also for the oocyte
  publication-title: Reproduction fertility Dev
  doi: 10.1071/RD22204
– volume: 92
  year: 2007
  ident: B75
  article-title: Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2006-1665
– volume: 50
  start-page: 38
  year: 1994
  ident: B43
  article-title: Effects of interleukin-6 on proliferation and follicle-stimulating hormone-induced estradiol production by bovine granulosa cells in vitro: dependence on size of follicle
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod50.1.38
– volume: 100
  year: 2013
  ident: B79
  article-title: Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation
  publication-title: Fertility sterility
  doi: 10.1016/j.fertnstert.2013.04.022
– volume: 169
  year: 1993
  ident: B86
  article-title: Ovarian cortex surrounding benign neoplasms: a histologic study
  publication-title: Am J obstetrics gynecology
  doi: 10.1016/0002-9378(93)90093-X
– volume: 366
  year: 2012
  ident: B113
  article-title: Cumulative birth rates with linked assisted reproductive technology cycles
  publication-title: New Engl J Med
  doi: 10.1056/NEJMoa1110238
– volume: 8
  year: 2001
  ident: B7
  article-title: Aging and proinflammatory cytokines
  publication-title: Curr Opin Hematol
  doi: 10.1097/00062752-200105000-00001
– volume: 13
  year: 2022
  ident: B89
  article-title: Endometriosis-associated infertility: From pathophysiology to tailored treatment
  publication-title: Front Endocrinol
  doi: 10.3389/fendo.2022.1020827
– volume: 81
  start-page: 19
  year: 2004
  ident: B53
  article-title: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
  publication-title: Fertility sterility
  doi: 10.1016/j.fertnstert.2003.10.004
– volume: 27
  year: 2020
  ident: B94
  article-title: Endometriosis: the role of iron overload and ferroptosis
  publication-title: Reprod Sci (Thousand Oaks Calif)
  doi: 10.1007/s43032-020-00164-z
– volume: 84
  year: 2020
  ident: B27
  article-title: Controlling chronic low-grade inflammation to improve follicle development and survival
  publication-title: Am J Reprod Immunol (New York NY: 1989)
  doi: 10.1111/aji.13265
– volume: 2
  start-page: 9
  year: 2009
  ident: B122
  article-title: Oocyte-granulosa-theca cell interactions during preantral follicular development
  publication-title: J Ovarian Res
  doi: 10.1186/1757-2215-2-9
– volume: 15
  year: 2016
  ident: B118
  article-title: Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway
  publication-title: Cell Cycle (Georgetown Tex)
  doi: 10.1080/15384101.2016.1208873
– volume: 18
  year: 2017
  ident: B1
  article-title: A guiding map for inflammation
  publication-title: Nat Immunol
  doi: 10.1038/ni.3790
– volume: 20
  year: 2014
  ident: B10
  article-title: Reactive oxygen species in inflammation and tissue injury
  publication-title: Antioxidants Redox Signaling
  doi: 10.1089/ars.2012.5149
– volume: 335
  start-page: 30
  year: 2011
  ident: B57
  article-title: The role of low-grade inflammation in the polycystic ovary syndrome
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2010.08.002
– volume: 365
  start-page: 591
  year: 2016
  ident: B14
  article-title: Reactive oxygen species and fibrosis: further evidence of a significant liaison
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-016-2445-3
– volume: 10
  year: 2022
  ident: B16
  article-title: Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2022.1038107
– volume: 352
  year: 2005
  ident: B73
  article-title: Polycystic ovary syndrome
  publication-title: New Engl J Med
  doi: 10.1056/NEJMra041536
– volume: 40
  year: 1994
  ident: B40
  article-title: Comparative IL-6 effects on FSH and hCG-induced functions in porcine granulosa cell cultures
  publication-title: Cell Mol Biol (Noisy-le-Grand France)
– volume: 14
  year: 2015
  ident: B69
  article-title: Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes
  publication-title: Cell Cycle (Georgetown Tex)
  doi: 10.1080/15384101.2015.1026517
– volume: 7
  start-page: 10824
  year: 2017
  ident: B83
  article-title: Activation of endoplasmic reticulum stress in granulosa cells from patients with polycystic ovary syndrome contributes to ovarian fibrosis
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-11252-7
– volume: 16
  year: 1999
  ident: B116
  article-title: Cytokines in older patients undergoing in vitro fertilization: the relationship to the response to controlled ovarian hyperstimulation
  publication-title: J assisted Reprod Genet
  doi: 10.1023/A:1020363312252
– volume: 93
  year: 2010
  ident: B100
  article-title: Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis
  publication-title: Fertility sterility
  doi: 10.1016/j.fertnstert.2009.08.068
– volume: 102
  start-page: 151
  year: 2014
  ident: B107
  article-title: Dynamics of nitric oxide, altered follicular microenvironment, and oocyte quality in women with endometriosis
  publication-title: Fertility sterility
  doi: 10.1016/j.fertnstert.2014.03.053
– volume: 611
  year: 2022
  ident: B127
  article-title: Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes
  publication-title: Nature
  doi: 10.1038/s41586-022-05388-4
– volume: 13
  year: 2017
  ident: B96
  article-title: ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.2239
– volume: 8
  year: 1998
  ident: B32
  article-title: Tumor necrosis factor-alpha (TNF-alpha) inhibits steroidogenesis of bovine ovarian granulosa and thecal cells in vitro. Involvement of TNF-alpha receptors
  publication-title: Endocrine
  doi: 10.1385/ENDO:8:2:109
– volume: 36
  start-page: 1
  year: 2015
  ident: B24
  article-title: Intraovarian control of early folliculogenesis
  publication-title: Endocrine Rev
  doi: 10.1210/er.2014-1020
– volume: 125
  start-page: 79
  year: 2015
  ident: B87
  article-title: Influence of endometriosis on assisted reproductive technology outcomes: a systematic review and meta-analysis
  publication-title: Obstetrics gynecology
  doi: 10.1097/AOG.0000000000000592
– volume: 137
  year: 1996
  ident: B28
  article-title: Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles
  publication-title: Endocrinology
  doi: 10.1210/endo.137.11.8895358
– volume: 20
  year: 2021
  ident: B18
  article-title: The role of pituitary gonadotropins and intraovarian regulators in follicle development: A mini-review
  publication-title: Reprod Med Biol
  doi: 10.1002/rmb2.12371
– volume: 29
  start-page: 1
  year: 2023
  ident: B22
  article-title: Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmac031
– volume: 217
  year: 2020
  ident: B15
  article-title: Transforming growth factor-β in tissue fibrosis
  publication-title: J Exp Med
  doi: 10.1084/jem.20190103
– volume: 155
  year: 2014
  ident: B44
  article-title: IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation
  publication-title: Endocrinology
  doi: 10.1210/en.2013-1821
– volume: 14
  year: 2008
  ident: B119
  article-title: Cellular and molecular aspects of ovarian follicle ageing
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmm048
– volume: 149
  year: 2012
  ident: B95
  article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.042
– volume: 128
  year: 1991
  ident: B76
  article-title: Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytes
  publication-title: Endocrinology
  doi: 10.1210/endo-128-1-379
– volume: 294
  year: 2002
  ident: B29
  article-title: Induction of apoptosis in granulosa cells by TNF alpha and its attenuation by glucocorticoids involve modulation of Bcl-2
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/S0006-291X(02)00431-X
– volume: 13
  start-page: 81
  year: 2017
  ident: B97
  article-title: Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.2238
– volume: 28
  year: 2012
  ident: B49
  article-title: Effect of follicular fluid oxidative stress parameters on intracytoplasmic sperm injection outcome
  publication-title: Gynecological endocrinology: Off J Int Soc Gynecological Endocrinol
  doi: 10.3109/09513590.2011.579652
– volume: 31
  start-page: 291
  year: 2018
  ident: B55
  article-title: Source and amount of carbohydrate in the diet and inflammation in women with polycystic ovary syndrome
  publication-title: Nutr Res Rev
  doi: 10.1017/S0954422418000136
– volume: 93
  year: 2010
  ident: B34
  article-title: Effects of tumor necrosis factor-alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment
  publication-title: Fertility sterility
  doi: 10.1016/j.fertnstert.2009.01.131
– volume: 40
  year: 2019
  ident: B85
  article-title: Endometriosis
  publication-title: Endocrine Rev
  doi: 10.1210/er.2018-00242
– volume: 34
  year: 2018
  ident: B60
  article-title: Evaluation of pro-oxidant-antioxidant balance (PAB) and its association with inflammatory cytokines in polycystic ovary syndrome (PCOS)
  publication-title: Gynecological endocrinology: Off J Int Soc Gynecological Endocrinol
  doi: 10.1080/09513590.2017.1371691
– volume: 96
  year: 2011
  ident: B101
  article-title: Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis
  publication-title: Fertility sterility
  doi: 10.1016/j.fertnstert.2011.06.064
– year: 2014
  ident: B114
  article-title: Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
  publication-title: journals gerontology Ser A Biol Sci Med Sci
  doi: 10.1093/gerona/glu057
– volume: 12
  start-page: 1454
  year: 2023
  ident: B54
  article-title: Polycystic ovary syndrome: etiology, current management, and future therapeutics
  publication-title: J Clin Med
  doi: 10.3390/jcm12041454
– volume: 14
  year: 2023
  ident: B104
  article-title: Iron overload triggering ECM-mediated Hippo/YAP pathway in follicle development: a hypothetical model endowed with therapeutic implications
  publication-title: Front Endocrinol
  doi: 10.3389/fendo.2023.1174817
– year: 1995
  ident: B105
  article-title: Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction
  publication-title: Hum Reprod (Oxford England)
  doi: 10.1093/humrep/10.suppl_2.91
– volume: 13
  year: 2022
  ident: B109
  article-title: Is oocyte quality impaired in cases with ovarian endometriosis? A second look into the clinical setting
  publication-title: Front Endocrinol
  doi: 10.3389/fendo.2022.921032
– volume: 30
  start-page: 97
  year: 2017
  ident: B72
  article-title: Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges
  publication-title: Nutr Res Rev
  doi: 10.1017/S0954422416000287
– volume: 160
  year: 2015
  ident: B2
  article-title: Homeostasis, inflammation, and disease susceptibility
  publication-title: Cell
  doi: 10.1016/j.cell.2015.02.010
– volume: 136
  year: 1995
  ident: B36
  article-title: Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production
  publication-title: Endocrinology
  doi: 10.1210/endo.136.7.7540548
– volume: 28
  year: 2013
  ident: B82
  article-title: Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats
  publication-title: Hum Reprod (Oxford England)
  doi: 10.1093/humrep/det341
– volume: 103
  year: 2015
  ident: B48
  article-title: Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health
  publication-title: Fertility sterility
  doi: 10.1016/j.fertnstert.2014.11.015
– volume: 41
  year: 2019
  ident: B38
  article-title: Chronic low-grade inflammation in polycystic ovary syndrome: is there a (patho)-physiological role for interleukin-1
  publication-title: Semin immunopathology
  doi: 10.1007/s00281-019-00737-4
– volume: 9
  year: 1994
  ident: B106
  article-title: Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation
  publication-title: Hum Reprod (Oxford England)
  doi: 10.1093/oxfordjournals.humrep.a138578
– volume: 29
  year: 2014
  ident: B93
  article-title: Iron availability is increased in individual human ovarian follicles in close proximity to an endometrioma compared with distal ones
  publication-title: Hum Reprod (Oxford England)
  doi: 10.1093/humrep/det466
– volume: 28
  year: 2017
  ident: B71
  article-title: Oocyte competence in women with polycystic ovary syndrome
  publication-title: Trends Endocrinol metabolism: TEM
  doi: 10.1016/j.tem.2016.11.008
– volume: 17
  year: 2018
  ident: B67
  article-title: Loss of TIGAR induces oxidative stress and meiotic defects in oocytes from obese mice
  publication-title: Mol Cell proteomics: MCP
  doi: 10.1074/mcp.RA118.000620
– volume: 37
  year: 1998
  ident: B35
  article-title: Interleukin-1 beta fragment (163-171) modulates bovine granulosa cell proliferation in vitro: dependence on size of follicle
  publication-title: J Reprod Immunol
  doi: 10.1016/S0165-0378(97)00077-6
– volume: 30
  year: 1998
  ident: B110
  article-title: Declining fecundity and ovarian ageing in natural fertility populations
  publication-title: Maturitas
  doi: 10.1016/S0378-5122(98)00068-1
– volume: 18
  year: 2012
  ident: B12
  article-title: Mechanisms of fibrosis: therapeutic translation for fibrotic disease
  publication-title: Nat Med
  doi: 10.1038/nm.2807
– volume: 17
  start-page: 17
  year: 2011
  ident: B62
  article-title: Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmq032
– volume: 8
  start-page: 18
  year: 2009
  ident: B8
  article-title: Molecular inflammation: underpinnings of aging and age-related diseases
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2008.07.002
– volume: 234
  year: 2019
  ident: B120
  article-title: CCL5 secreted by senescent theca-interstitial cells inhibits preantral follicular development via granulosa cellular apoptosis
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.28819
– volume: 152
  year: 2016
  ident: B45
  article-title: Reproductive age-associated fibrosis in the stroma of the mammalian ovary
  publication-title: Reprod (Cambridge England)
  doi: 10.1530/REP-16-0129
– volume: 11
  start-page: 278
  year: 2021
  ident: B46
  article-title: Evaluation of inflammation and follicle depletion during ovarian ageing in mice
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-79488-4
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Snippet The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS),...
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SubjectTerms Aging
Endocrinology
Endometriosis
Female
Fibrosis
follicular microenvironment
Humans
inflammation
Inflammation - complications
ovarian dysfunction
polycystic ovarian syndrome
Polycystic Ovary Syndrome - complications
Tumor Microenvironment
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Title Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging
URI https://www.ncbi.nlm.nih.gov/pubmed/38192421
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