Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging

The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammatio...

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Published inFrontiers in endocrinology (Lausanne) Vol. 14; p. 1324429
Main Authors Orisaka, Makoto, Mizutani, Tetsuya, Miyazaki, Yumiko, Shirafuji, Aya, Tamamura, Chiyo, Fujita, Masayuki, Tsuyoshi, Hideaki, Yoshida, Yoshio
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.12.2023
Subjects
Aging
Endocrinology
Endometriosis
Female
Fibrosis
follicular microenvironment
Humans
inflammation
Inflammation - complications
ovarian dysfunction
polycystic ovarian syndrome
Polycystic Ovary Syndrome - complications
Tumor Microenvironment
endometriosis
aging
follicular microenvironment
inflammation
ovarian dysfunction
polycystic ovarian syndrome
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Summary:The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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Fardin Amidi, Tehran University of Medical Sciences, Iran
Reviewed by: Miyuki Harada, The University of Tokyo, Japan
Edited by: Takashi Minegishi, Gunma University, Japan
Takashi Yazawa, Asahikawa Medical University, Japan
Akira Iwase, Gunma University, Japan
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2023.1324429